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Characterization of one-year progression of risk phenotypes of diabetic retinopathy 

2022Journal article Open access
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dc.contributor.authorRibeiro, Luísa
dc.contributor.authorMarques, Inês P.
dc.contributor.authorCoimbra, Rita
dc.contributor.authorSantos, Torcato
dc.contributor.authorMadeira, Maria H.
dc.contributor.authorSantos, Ana Rita
dc.contributor.authorBarreto, Patrícia
dc.contributor.authorLobo, Conceição
dc.contributor.authorCunha-Vaz, José
dc.date.accessioned2023-01-31T15:34:36Z
dc.date.available2023-01-31T15:34:36Z
dc.date.issued2022
dc.description.abstractWe characterized the progression of different diabetic retinopathy (DR) phenotypes in type 2 diabetes (T2D). A prospective longitudinal cohort study (CORDIS, NCT03696810) was conducted with three visits (baseline, 6 months, and 1 year). Demographic and systemic data included age, sex, diabetes duration, lipid profile, and hemoglobin A1c (HbA1c). Ophthalmological examinations included best-corrected visual acuity (BCVA), color fundus photography (CFP), and optical coherence tomography (OCT and OCTA). Phenotype classification was performed at the 6-month visit based on microaneurysm turnover (MAT, on CFP) and central retinal thickness (CRT, on OCT). Only risk phenotypes B (MAT < 6 and increased CRT) and C (MAT ≥ 6 with or without increased CRT) were included. ETDRS grading was performed at the baseline visit based on seven-field CFP.A total of 133 T2D individuals were included in the study; 81 (60%) eyes were classified as phenotype B and 52 (40%) eyes as phenotype C. Of these, 128 completed the 1-year follow-up. At baseline, eyes with phenotype C showed greater capillary closure (superior capillary plexus, deep capillary plexus, and full retina, p < 0.001) and increased foveal avascular zone (FAZ) area (p < 0.001), indicating more advanced microvascular disease. Neurodegeneration represented by thinning of the ganglion cell layer + inner plexiform layer (GCL + IPL) was present in both phenotypes. When analyzing the 1-year progression of each phenotype, only phenotype C revealed a significant decrease in BCVA (p = 0.02) and enlargement of the FAZ (p = 0.03). A significant progressive decrease in the vessel density of the deep capillary layer and in MAT occurred in both phenotypes, but these changes were particularly relevant in phenotype C and ETDRS grades 43–47. During the 1-year period, both phenotypes B and C showed progression in GCL + IPL thinning (p < 0.001). In the 1-year period of follow-up, both phenotypes B and C showed progression in retinal neurodegeneration, whereas phenotype C showed more marked disease progression at the microvascular level.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRibeiro, L., Marques, I.P., Coimbra, R. et al. Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy. Ophthalmol Ther 11, 333–345 (2022). https://doi.org/10.1007/s40123-021-00437-zpt_PT
dc.identifier.doi10.1007/s40123-021-00437-zpt_PT
dc.identifier.eissn2193-6528
dc.identifier.issn2193-8245
dc.identifier.urihttp://hdl.handle.net/10400.22/22039
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s40123-021-00437-zpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectDiabetespt_PT
dc.subjectRetinopathypt_PT
dc.subjectCapillary closurept_PT
dc.subjectNeurodegenerationpt_PT
dc.titleCharacterization of one-year progression of risk phenotypes of diabetic retinopathy pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage345pt_PT
oaire.citation.startPage333pt_PT
oaire.citation.titleOphthalmology and Therapypt_PT
oaire.citation.volume11pt_PT
person.familyNameSantos
person.givenNameAna Rita
person.identifier.ciencia-id0911-4138-0C3A
person.identifier.orcid0000-0003-0139-0285
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd71931b8-d869-4334-993c-ba14ad713f01
relation.isAuthorOfPublication.latestForDiscoveryd71931b8-d869-4334-993c-ba14ad713f01

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