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Profiling persistent asthma phenotypes in adolescents: A longitudinal diagnostic evaluation from the INSPIRERS Studies

2021-01-01Journal article Open access
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dc.contributor.authorAmaral, Rita
dc.contributor.authorJácome, Cristina
dc.contributor.authorAlmeida, Rute
dc.contributor.authorPereira, Ana M.
dc.contributor.authorAlves-Correia, Magna
dc.contributor.authorMendes, Sandra
dc.contributor.authorRodrigues, José C.
dc.contributor.authorCarvalho, Joana
dc.contributor.authorAraújo, Luís
dc.contributor.authorCosta, Alberto
dc.contributor.authorSilva, Armandina
dc.contributor.authorTeixeira, Maria F.
dc.contributor.authorFerreira-Magalhães, Manuel
dc.contributor.authorAlves, Rodrigo R.
dc.contributor.authorMoreira, Ana S.
dc.contributor.authorFernandes, Ricardo M.
dc.contributor.authorFerreira, Rosário
dc.contributor.authorPinto, Paula L.
dc.contributor.authorNeuparth, Nuno
dc.contributor.authorBordalo, Diana
dc.contributor.authorBom, Ana T.
dc.contributor.authorCálix, Maria J.
dc.contributor.authorFerreira, Tânia
dc.contributor.authorGomes, Joana
dc.contributor.authorVidal, Carmen
dc.contributor.authorMendes, Ana
dc.contributor.authorVasconcelos, Maria J.
dc.contributor.authorSilva, Pedro M.
dc.contributor.authorFerraz, José
dc.contributor.authorMorête, Ana
dc.contributor.authorPinto, Claúdia S.
dc.contributor.authorSantos, Natacha
dc.contributor.authorLoureiro, Carla C.
dc.contributor.authorCâmara, Raquel
dc.contributor.authorVieira, Inês
dc.contributor.authorSilva, Sofia D.
dc.contributor.authorSilva, Eurico
dc.contributor.authorRodrigues, Natalina
dc.contributor.authorFonseca, João A.
dc.date.accessioned2021-04-07T09:06:44Z
dc.date.available2021-04-07T09:06:44Z
dc.date.issued2021-01-01
dc.description.abstractWe aimed to identify persistent asthma phenotypes among adolescents and to evaluate longitudinally asthma-related outcomes across phenotypes. Adolescents (13–17 years) from the prospective, observational, and multicenter INSPIRERS studies, conducted in Portugal and Spain, were included (n = 162). Latent class analysis was applied to demographic, environmental, and clinical variables, collected at a baseline medical visit. Longitudinal differences in clinical variables were assessed at a 4-month follow-up telephone contact (n = 128). Three classes/phenotypes of persistent asthma were identified. Adolescents in class 1 (n = 87) were highly symptomatic at baseline and presented the highest number of unscheduled healthcare visits per month and exacerbations per month, both at baseline and follow-up. Class 2 (n = 32) was characterized by female predominance, more frequent obesity, and uncontrolled upper/lower airways symptoms at baseline. At follow-up, there was a significant increase in the proportion of controlled lower airway symptoms (p < 0.001). Class 3 (n = 43) included mostly males with controlled lower airways symptoms; at follow-up, while keeping symptom control, there was a significant increase in exacerbations/month (p = 0.015). We have identified distinct phenotypes of persistent asthma in adolescents with different patterns in longitudinal asthma-related outcomes, supporting the importance of profiling asthma phenotypes in predicting disease outcomes that might inform targeted interventions and reduce future risk.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAmaral, R., Jácome, C., Almeida, R., Pereira, A. M., Alves-Correia, M., Mendes, S., Rodrigues, J. C., Carvalho, J., Araújo, L., Costa, A., Silva, A., Teixeira, M. F., Ferreira-Magalhães, M., Alves, R. R., Moreira, A. S., Fernandes, R. M., Ferreira, R., Pinto, P. L., Neuparth, N., Bordalo, D., Bom, A. T., Cálix, M. J., Ferreira, T., Gomes, J., Vidal, C., Mendes, A., Vasconcelos, M. J., Silva, P. M., Ferraz, J., Morête, A., Pinto, C. S., Santos, N., Loureiro, C. C., Arrobas, A., Marques, M. L., Lozoya, C., Lopes, C., Cardia, F., Loureiro, C. C., Câmara, R., Vieira, I., Silva, S. D., Silva, E., Rodrigues, N., & Fonseca, J. A. (2021). Profiling Persistent Asthma Phenotypes in Adolescents: A Longitudinal Diagnostic Evaluation from the INSPIRERS Studies. International Journal of Environmental Research and Public Health, 18(3). https://doi.org/10.3390/ijerph18031015pt_PT
dc.identifier.doi10.3390/ijerph18031015pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/17802
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1660-4601/18/3/1015pt_PT
dc.subjectAsthmapt_PT
dc.subjectAdolescentspt_PT
dc.subjectPhenotypespt_PT
dc.subjectClusteringpt_PT
dc.subjectLongitudinal studiespt_PT
dc.subjectLatent class analysispt_PT
dc.titleProfiling persistent asthma phenotypes in adolescents: A longitudinal diagnostic evaluation from the INSPIRERS Studiespt_PT
dc.typejournal article
dspace.entity.typePublication
person.familyNameAmaral
person.givenNameRita
person.identifierR-00H-83K
person.identifier.ciencia-id1A1E-751F-50F0
person.identifier.orcid0000-0002-0233-830X
person.identifier.ridE-5535-2017
person.identifier.scopus-author-id56067841600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication790fdd33-acdb-4dfe-88dc-38538486c9b3
relation.isAuthorOfPublication.latestForDiscovery790fdd33-acdb-4dfe-88dc-38538486c9b3

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