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Orientador(es)
Resumo(s)
We aimed to identify persistent asthma phenotypes among adolescents and to evaluate longitudinally asthma-related outcomes across phenotypes. Adolescents (13–17 years) from the prospective, observational, and multicenter INSPIRERS studies, conducted in Portugal and Spain, were included (n = 162). Latent class analysis was applied to demographic, environmental, and clinical variables, collected at a baseline medical visit. Longitudinal differences in clinical variables were assessed at a 4-month follow-up telephone contact (n = 128). Three classes/phenotypes of persistent asthma were identified. Adolescents in class 1 (n = 87) were highly symptomatic at baseline and presented the highest number of unscheduled healthcare visits per month and exacerbations per month, both at baseline and follow-up. Class 2 (n = 32) was characterized by female predominance, more frequent obesity, and uncontrolled upper/lower airways symptoms at baseline. At follow-up, there was a significant increase in the proportion of controlled lower airway symptoms (p < 0.001). Class 3 (n = 43) included mostly males with controlled lower airways symptoms; at follow-up, while keeping symptom control, there was a significant increase in exacerbations/month (p = 0.015). We have identified distinct phenotypes of persistent asthma in adolescents with different patterns in longitudinal asthma-related outcomes, supporting the importance of profiling asthma phenotypes in predicting disease outcomes that might inform targeted interventions and reduce future risk.
Descrição
Palavras-chave
Asthma Adolescents Phenotypes Clustering Longitudinal studies Latent class analysis
Contexto Educativo
Citação
Amaral, R., Jácome, C., Almeida, R., Pereira, A. M., Alves-Correia, M., Mendes, S., Rodrigues, J. C., Carvalho, J., Araújo, L., Costa, A., Silva, A., Teixeira, M. F., Ferreira-Magalhães, M., Alves, R. R., Moreira, A. S., Fernandes, R. M., Ferreira, R., Pinto, P. L., Neuparth, N., Bordalo, D., Bom, A. T., Cálix, M. J., Ferreira, T., Gomes, J., Vidal, C., Mendes, A., Vasconcelos, M. J., Silva, P. M., Ferraz, J., Morête, A., Pinto, C. S., Santos, N., Loureiro, C. C., Arrobas, A., Marques, M. L., Lozoya, C., Lopes, C., Cardia, F., Loureiro, C. C., Câmara, R., Vieira, I., Silva, S. D., Silva, E., Rodrigues, N., & Fonseca, J. A. (2021). Profiling Persistent Asthma Phenotypes in Adolescents: A Longitudinal Diagnostic Evaluation from the INSPIRERS Studies. International Journal of Environmental Research and Public Health, 18(3). https://doi.org/10.3390/ijerph18031015