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Noncompliance to iodine supplementation recommendation is a risk factor for iodine insufficiency in portuguese pregnant women: results from the IoMum cohort

2022-05-30Journal article Restricted access
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dc.contributor.authorMatta Coelho, C.
dc.contributor.authorGuimarães, J.
dc.contributor.authorBracchi, I.
dc.contributor.authorXavier Moreira, N.
dc.contributor.authorPinheiro, C.
dc.contributor.authorFerreira, P.
dc.contributor.authorPestana, D.
dc.contributor.authorBarreiros Mota, I.
dc.contributor.authorCortez, A.
dc.contributor.authorPrucha, C.
dc.contributor.authorMartins, C.
dc.contributor.authorPinto, E.
dc.contributor.authorAlmeida, A.
dc.contributor.authorDelerue‑Matos, C.
dc.contributor.authorC. Dias, C.
dc.contributor.authorMoreira‑Rosário, A.
dc.contributor.authorF. Ribeiro de Azevedo, L.
dc.contributor.authorCruz Fernandes, V.
dc.contributor.authorRamalho, C.
dc.contributor.authorCalhau, C.
dc.contributor.author‑L. Brantsæter, A.
dc.contributor.authorCosta Leite, J.
dc.contributor.authorKeating, E.
dc.date.accessioned2023-01-17T12:30:22Z
dc.date.available2023-05-30T00:33:45Z
dc.date.issued2022-05-30
dc.description.abstractAfter a recommendation for iodine supplementation in pregnancy has been issued in 2013 in Portugal, there were no studies covering iodine status in pregnancy in the country. The aim of this study was to assess iodine status in pregnant women in Porto region and its association with iodine supplementation. A cross-sectional study was conducted at Centro Hospitalar Universitário São João, Porto, from April 2018 to April 2019. Pregnant women attending the 1st trimester ultrasound scan were invited to participate. Exclusion criteria were levothyroxine use, gestational age<10 and≥14 weeks, non-evolutive pregnancy at recruitment and non-signing of informed consent. Urinary iodine concentration (UIC) was measured in random spot urine by inductively coupled plasma-mass spectrometry. Median UIC was 104 μg/L (IQR 62–189) in the overall population (n=481) of which 19% had UIC<50 µg/L. Forty three percent (n=206) were not taking an iodine-containing supplement (ICS) and median UIC values were 146 µg/L (IQR 81–260) and 74 µg/L (IQR 42–113) in ICS users and non-users, respectively (p<0.001). Not using an ICS was an independent risk factor for iodine insufciency [adjusted OR (95% CI)=6.00 (2.74, 13.16); p<0.001]. Iodised salt use was associated with increased median iodine-to-creatinine ratio (p<0.014). A low compliance to iodine supplementation recommendation in pregnancy accounted for a mild-to-moderately iodine defciency. Our results evidence the need to support iodine supplementation among pregnant women in countries with low household coverage of iodised salt.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMatta Coelho, C., Guimarães, J., Bracchi, I. et al. Noncompliance to iodine supplementation recommendation is a risk factor for iodine insufficiency in Portuguese pregnant women: results from the IoMum cohort. J Endocrinol Invest 45, 1865–1874 (2022). https://doi.org/10.1007/s40618-022-01813-7pt_PT
dc.identifier.doi10.1007/s40618-022-01813-7pt_PT
dc.identifier.eissn1720-8386
dc.identifier.issn0391-4097
dc.identifier.urihttp://hdl.handle.net/10400.22/21591
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s40618-022-01813-7#citeaspt_PT
dc.subjectPregnancypt_PT
dc.subjectUrinary iodinept_PT
dc.subjectIodine supplement usept_PT
dc.subjectIodine statuspt_PT
dc.subjectIodine defciencypt_PT
dc.titleNoncompliance to iodine supplementation recommendation is a risk factor for iodine insufficiency in portuguese pregnant women: results from the IoMum cohortpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1874pt_PT
oaire.citation.startPage1865pt_PT
oaire.citation.titleJournal of Endocrinological Investigationpt_PT
oaire.citation.volume45pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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