Publication
Phylogenetic Insights of β-lactam resistance of the CTX-M family
| dc.contributor.author | Coelho, Pedro Barata | |
| dc.contributor.author | Mendonça, Jacinta | |
| dc.contributor.author | Silva, Carina | |
| dc.contributor.author | Baylina, Pilar | |
| dc.contributor.author | Fernandes, Ruben | |
| dc.contributor.author | Guedes, Carla | |
| dc.date.accessioned | 2024-10-15T14:10:04Z | |
| dc.date.available | 2024-10-15T14:10:04Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Bacterial resistance is a major public health concern, particularly against β-lactam antibiotics, one of the most widely used antibacterial drugs. The production of extended-spectrum β-lactamases (ESBLs) is the main defense mechanism found in Gram negative bacteria. Among all the ESBLs, the CTX-M enzymes appear as the most efficient in terms of diffusion in different epidemiological contexts, outnumbering the others. Originated in chromosomal genes of Klyvera spp., the blaCTX-M genes have become associated with mobile genetic elements, such as plasmids, that have mediated inter-replication and dissemination. CTX-M enzymes exhibit a striking plasticity, with a large number of allelic variants belonging to several sub-lineages, which can be associated with functional heterogeneity of clinical relevance. This observational analytical study provides an update of this family, currently with more than 200 variants described, from a phylogenetic, molecular and structural point of view through homology in amino acid sequences. There are currently 6 defined clusters (CTX-M-1, CTX-M-2, CTX-M-8, CTX-M-9, CTX-M-25 and CTX-M-151), with the domains CTX -M-1 and CTX-M-9 presenting subgroups, composed mainly of variants identified as hybrids between them (particularly between CTX-M-14 and CTX-M-15). | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Coelho, P. B., Mendonça, J., Silva, C., Baylina, P., Fernandes, R., & Guedes, C. (2021). Phylogenetic Insights of β-lactam resistance of the CTX-M family. Livro de resumos XXVIII Congreso Nacional de Microbiología, 188. | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.22/26243 | |
| dc.language.iso | eng | pt_PT |
| dc.publisher | Sociedade Espanhola de Microbiologia | pt_PT |
| dc.relation.publisherversion | https://digital.csic.es/bitstream/10261/270690/1/XVIII-Congreso-Nacional-de-Microbiologi%CC%81a-FINAL-7.pdf | pt_PT |
| dc.subject | β-lactam | pt_PT |
| dc.subject | CTX-M family | pt_PT |
| dc.title | Phylogenetic Insights of β-lactam resistance of the CTX-M family | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.startPage | 188 | pt_PT |
| oaire.citation.title | Livro de resumos XXVIII Congreso Nacional de Microbiología | pt_PT |
| person.familyName | BAYLINA MACHADO | |
| person.familyName | Fernandes | |
| person.familyName | Guedes | |
| person.givenName | PILAR | |
| person.givenName | Rúben | |
| person.givenName | Carla | |
| person.identifier | 635792 | |
| person.identifier | 1888845 | |
| person.identifier.ciencia-id | 1419-F23D-4920 | |
| person.identifier.ciencia-id | 0D1F-4090-E82A | |
| person.identifier.ciencia-id | 2B11-8C00-A60D | |
| person.identifier.orcid | 0000-0002-3740-862X | |
| person.identifier.orcid | 0000-0001-8933-3984 | |
| person.identifier.orcid | 0000-0002-3277-7821 | |
| person.identifier.rid | B-5134-2010 | |
| person.identifier.rid | D-3704-2017 | |
| person.identifier.scopus-author-id | 56534079700 | |
| person.identifier.scopus-author-id | 57640135700 | |
| person.identifier.scopus-author-id | 57447314300 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
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