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Bridging cyanobacteria to neurodegenerative diseases: a new potential source of bioactive compounds against Alzheimer’s disease

2021-06-16Journal article Open access
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dc.contributor.authorCastaneda, Andrea
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorVieira, Mónica
dc.contributor.authorCardoso, Isabel
dc.contributor.authorVasconcelos, Vítor
dc.contributor.authorMartins, Rosário
dc.date.accessioned2021-07-06T11:35:56Z
dc.date.available2021-07-06T11:35:56Z
dc.date.issued2021-06-16
dc.description.abstractNeurodegenerative diseases (NDs) represent a drawback in society given the ageing population. Dementias are the most prevalent NDs, with Alzheimer’s disease (AD) representing around 70% of all cases. The current pharmaceuticals for AD are symptomatic and with no effects on the progression of the disease. Thus, research on molecules with therapeutic relevance has become a major focus for the scientific community. Cyanobacteria are a group of photosynthetic prokaryotes rich in biomolecules with confirmed activity in pathologies such as cancer, and with feasible potential in NDs such as AD. In this review, we aimed to compile the research works focused in the anti-AD potential of cyanobacteria, namely regarding the inhibition of the enzyme β-secretase (BACE1) as a fundamental enzyme in the generation of β-amyloid (Aβ), the inhibition of the enzyme acetylcholinesterase (AChE) lead to an increase in the availability of the neurotransmitter acetylcholine in the synaptic cleft and the antioxidant and anti-inflammatory effects, as phenomena associated with neurodegeneration mechanisms.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCastaneda, A., Ferraz, R., Vieira, M., Cardoso, I., Vasconcelos, V., & Martins, R. (2021). Bridging Cyanobacteria to Neurodegenerative Diseases: A New Potential Source of Bioactive Compounds against Alzheimer’s Disease. Marine Drugs, 19(6), 343. https://www.mdpi.com/1660-3397/19/6/343pt_PT
dc.identifier.doi10.3390/md19060343pt_PT
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/10400.22/18089
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1660-3397/19/6/343/htmpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCyanobacteriapt_PT
dc.subjectAlzheimer’s diseasept_PT
dc.subjectNatural productspt_PT
dc.subjectNew therapiespt_PT
dc.titleBridging cyanobacteria to neurodegenerative diseases: a new potential source of bioactive compounds against Alzheimer’s diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage21pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleMarine Drugspt_PT
oaire.citation.volume19pt_PT
person.familyNameFerraz
person.familyNameVieira
person.familyNameMartins
person.givenNameRicardo
person.givenNameMónica
person.givenNameRosario
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.ciencia-idA919-DB40-EF10
person.identifier.orcid0000-0002-1761-117X
person.identifier.orcid0000-0002-9614-9031
person.identifier.orcid0000-0002-9882-4651
person.identifier.ridG-5639-2011
person.identifier.ridD-8977-2016
person.identifier.scopus-author-id24464208500
person.identifier.scopus-author-id24464652500
person.identifier.scopus-author-id21834368700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa5a8faa7-12a5-4b1c-bced-44c895677397
relation.isAuthorOfPublication55587c4b-3df0-4ff1-bade-587420940ecd
relation.isAuthorOfPublication82a7c349-c88e-450f-adc7-3331d69149cf
relation.isAuthorOfPublication.latestForDiscovery82a7c349-c88e-450f-adc7-3331d69149cf

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