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Functionalized liposomes and phytosomes loading Annona muricata L. aqueous extract: Potential nanoshuttles for brain-delivery of phenolic compounds

2018-01Artigo científico Acesso aberto
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dc.contributor.authorMancini, Simona
dc.contributor.authorNardo, Luca
dc.contributor.authorGregori, Maria
dc.contributor.authorRibeiro, Inês
dc.contributor.authorMantegazza, Francesco
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorMasserini, Massimo
dc.contributor.authorGrosso, Clara
dc.date.accessioned2019-10-07T14:29:02Z
dc.date.available2019-10-07T14:29:02Z
dc.date.issued2018-01
dc.description.abstractMulti-target drugs have gained significant recognition for the treatment of multifactorial diseases such as depression. Under a screening study of multi-potent medicinal plants with claimed antidepressant-like activity, the phenolic-rich Annona muricata aqueous extract (AE) emerged as a moderate monoamine oxidase A (hMAO-A) inhibitor and a strong hydrogen peroxide (H2O2) scavenger.pt_PT
dc.description.sponsorshipThis work was financed through project UID/QUI/50006/2013, receiving financial support from FCT/MEC through national funds, and co-financed by FEDER, under the Partnership Agreement PT2020. C. G. thanks FCT for the FCT Investigator(/IF/01332/2014/CP1255/CT0001). The authors would also like to acknowledge Sílvia Maia from CEMUP for her technical assistance with LTQ Orbitrap XL analyses and to Professor Michael Clifford for his advices in analyzing the MS spectra of phenolic acids.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.phymed.2018.03.053
dc.identifier.issn0944-7113
dc.identifier.urihttp://hdl.handle.net/10400.22/14710
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0944711318300886?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAnnonapt_PT
dc.subjectAntioxidantspt_PT
dc.subjectBlood-Brain Barrierpt_PT
dc.subjectDrug Carrierspt_PT
dc.subjectEndothelial Cellspt_PT
dc.subjectFree Radical Scavengerspt_PT
dc.subjectHumanspt_PT
dc.subjectHydrogen Peroxidept_PT
dc.subjectLiposomespt_PT
dc.subjectMonoamine Oxidase Inhibitorspt_PT
dc.subjectNanostructurespt_PT
dc.subjectPhenolspt_PT
dc.subjectPlant Extractspt_PT
dc.titleFunctionalized liposomes and phytosomes loading Annona muricata L. aqueous extract: Potential nanoshuttles for brain-delivery of phenolic compoundspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F50006%2F2013/PT
oaire.citation.endPage244pt_PT
oaire.citation.startPage233pt_PT
oaire.citation.titlePhytomedicinept_PT
oaire.citation.volume42pt_PT
oaire.fundingStream5876
person.familyNameDelerue-Matos
person.givenNameCristina
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.orcid0000-0002-3924-776X
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id6603741848
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication09f6a7bd-2f15-42b0-adc5-04bd22210519
relation.isAuthorOfPublication.latestForDiscovery09f6a7bd-2f15-42b0-adc5-04bd22210519
relation.isProjectOfPublication5c06a623-3499-408c-aef9-0a1f68cb1d02
relation.isProjectOfPublication.latestForDiscovery5c06a623-3499-408c-aef9-0a1f68cb1d02

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