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Functionalized liposomes and phytosomes loading Annona muricata L. aqueous extract: Potential nanoshuttles for brain-delivery of phenolic compounds

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Multi-target drugs have gained significant recognition for the treatment of multifactorial diseases such as depression. Under a screening study of multi-potent medicinal plants with claimed antidepressant-like activity, the phenolic-rich Annona muricata aqueous extract (AE) emerged as a moderate monoamine oxidase A (hMAO-A) inhibitor and a strong hydrogen peroxide (H2O2) scavenger.

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Annona Antioxidants Blood-Brain Barrier Drug Carriers Endothelial Cells Free Radical Scavengers Humans Hydrogen Peroxide Liposomes Monoamine Oxidase Inhibitors Nanostructures Phenols Plant Extracts

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Springer

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