Functionalized liposomes and phytosomes loading Annona muricata L. aqueous extract: Potential nanoshuttles for brain-delivery of phenolic compounds

Mancini, Simona; Nardo, Luca; Gregori, Maria; Ribeiro, Inês; Mantegazza, Francesco; Delerue-Matos, Cristina; Masserini, Massimo; Grosso, Clara

http://hdl.handle.net/10400.22/14710

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Autores

Mantegazza, Francesco

Delerue-Matos, Cristina

Masserini, Massimo

Grosso, Clara

Resumo(s)

Multi-target drugs have gained significant recognition for the treatment of multifactorial diseases such as depression. Under a screening study of multi-potent medicinal plants with claimed antidepressant-like activity, the phenolic-rich Annona muricata aqueous extract (AE) emerged as a moderate monoamine oxidase A (hMAO-A) inhibitor and a strong hydrogen peroxide (H2O2) scavenger.

Palavras-chave

Annona Antioxidants Blood-Brain Barrier Drug Carriers Endothelial Cells Free Radical Scavengers Humans Hydrogen Peroxide Liposomes Monoamine Oxidase Inhibitors Nanostructures Phenols Plant Extracts