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Advisor(s)
Abstract(s)
Major depressive disorder affects over 350 million people around the world, and might result from a complex interaction of epigenetic, genetic, environmental and developmental factors. Antidepressants are a class of neuroactive compounds that are used mostly in the treatment of clinically severe mood and anxiety disorders, and can be divided into three major classes: tricyclic antidepressants, monoamine oxidase inhibitors and selective serotonin reuptake inhibitors. The boost on antidepressants’ prescription and consumption is related to an increase in the prevalence of psychiatric disorders and knowledge of mental health problems. These are considered emerging pollutants due to their omnipresence at trace levels in the environment. Nonetheless, the lack of knowledge concerning their impact on the environment, and consequently on aquatic species, highlights this topic as a pivotal concern. Even in low concentrations, antidepressants may cause several effects on the aquatic environment as a result of disturbing homeostasis throughout the central and peripheral nervous systems, both in vertebrates and in vertebrates, and by modifying the regulation of neurotransmitters such as serotonin, norepinephrine and dopamine. Zebrafish (Danio rerio), an aquatic vertebrate species, is one of the most important model organisms in developmental biology, considered extremely valuable for the study of translational neuroscience of complex human brain disorders, being particularly useful for studying genetic and pharmacological mechanisms of depression and antidepressant action.
Description
Keywords
Depression Venlafaxine Emerging pollutants Zebrafish
Citation
Barros, E., Abreu, I., Guimarães, L., & Melo, P. (2018). Effects of embryonic exposure to venlafaxine on a zebrafish model. Book of abstracts of the III Encontro de Biotecnologia Medicinal/ I Iberian Congress on Medicinal Biotechnology, 53. https://paginas.ess.ipp.pt/ebtm/2018/3EBtM_BookOfAbstracts.pdf
Publisher
Escola Superior de Saúde P.Porto