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Estrogen Metabolism-Associated CYP2D6 and IL6-174G/C Polymorphisms in Schistosoma haematobium Infection

2017Journal article Open access
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dc.contributor.authorCardoso, Rita
dc.contributor.authorLacerda, Pedro
dc.contributor.authorCosta, Paulo
dc.contributor.authorMachado, Ana
dc.contributor.authorCarvalho, André
dc.contributor.authorBordalo, Adriano
dc.contributor.authorFernandes, Rúben
dc.contributor.authorSoares, Raquel
dc.contributor.authorRichter, Joachim
dc.contributor.authorAlves, Helena
dc.contributor.authorBotelho, Monica
dc.date.accessioned2019-05-20T13:58:58Z
dc.date.available2019-05-20T13:58:58Z
dc.date.issued2017
dc.description.abstractSchistosoma haematobium is a human blood fluke causing a chronic infection called urogenital schistosomiasis. Squamous cell carcinoma of the urinary bladder (SCC) constitutes chronic sequelae of this infection, and S. haematobium infection is accounted as a risk factor for this type of cancer. This infection is considered a neglected tropical disease and is endemic in numerous countries in Africa and the Middle East. Schistosome eggs produce catechol-estrogens. These estrogenic molecules are metabolized to active quinones that induce modifications in DNA. The cytochrome P450 (CYP) enzymes are a superfamily of mono-oxygenases involved in estrogen biosynthesis and metabolism, the generation of DNA damaging procarcinogens, and the response to anti-estrogen therapies. IL6 Interleukin-6 (IL-6) is a pleiotropic cytokine expressed in various tissues. This cytokine is largely expressed in the female urogenital tract as well as reproductive organs. Very high or very low levels of IL-6 are associated with estrogen metabolism imbalance. In the present study, we investigated the polymorphic variants in the CYP2D6 gene and the C-174G promoter polymorphism of the IL-6 gene on S. haematobium-infected children patients from Guine Bissau. CYP2D6 inactivated alleles (28.5%) and IL6G-174C (13.3%) variants were frequent in S. haematobium-infected patients when compared to previously studied healthy populations (4.5% and 0.05%, respectively). Here we discuss our recent findings on these polymorphisms and whether they can be predictive markers of schistosome infection and/or represent potential biomarkers for urogenital schistosomiasis associated bladder cancer and infertility.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/ijms18122560pt_PT
dc.identifier.issn1661-6596
dc.identifier.urihttp://hdl.handle.net/10400.22/13750
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationPOCI-01-0145-FEDER-007274pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/18/12/2560pt_PT
dc.subjectAdolescentpt_PT
dc.subjectAnimalspt_PT
dc.subjectBody Mass Indexpt_PT
dc.subjectChildpt_PT
dc.subjectCytochrome P-450 CYP2D6pt_PT
dc.subjectEstrogenspt_PT
dc.subjectFemalept_PT
dc.subjectGenotypept_PT
dc.subjectHumanspt_PT
dc.subjectInterleukin-6pt_PT
dc.subjectMalept_PT
dc.subjectPolymorphism, Geneticpt_PT
dc.subjectSchistosoma haematobiumpt_PT
dc.subjectUrinary Bladder Neoplasmspt_PT
dc.titleEstrogen Metabolism-Associated CYP2D6 and IL6-174G/C Polymorphisms in Schistosoma haematobium Infectionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04293%2F2013/PT
oaire.citation.issue12pt_PT
oaire.citation.startPage2560pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume18pt_PT
oaire.fundingStream5876
person.familyNameFernandes
person.givenNameRúben
person.identifier635792
person.identifier.ciencia-id0D1F-4090-E82A
person.identifier.orcid0000-0001-8933-3984
person.identifier.scopus-author-id57640135700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication9e6c397c-62d8-4a40-8ec7-ad05ae0ebcc4
relation.isAuthorOfPublication.latestForDiscovery9e6c397c-62d8-4a40-8ec7-ad05ae0ebcc4
relation.isProjectOfPublicationa21beac1-88e1-4514-a951-aee8f9dd8cfc
relation.isProjectOfPublication.latestForDiscoverya21beac1-88e1-4514-a951-aee8f9dd8cfc

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