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- Allergen sensitization associates with worse lung function parametersPublication . Gonçalves, I.; Pereira, A. M.; Jacinto, Tiago; Amaral, Rita; Fonseca, J. de Almeida Lopes daTo assess the association between the number of allergen sensitizations and lung function variables in individuals with airway symptoms. Methods. Retrospective study with all individuals who performed lung function and skin-prick tests at CUF-Porto (01/2011-06/2016). Six allergen groups were considered. % predicted Pre-Bronchodilator test (BD) and % change after BD were analysed for spirometry and plethysmography parameters. Results. A total of 1293 individuals were included, 54% (n = 698) adults and 69% (n = 891) with sensitization to ≥ 1 allergen group. % FEV1 was significantly higher and % change in FEV1 significantly lower in non-sensitized individuals. % sRaw was higher in polysensitized (vs non-sensitized). Conclusions. The presence of allergen sensitizations was significantly associated with worse key lung function parameters.
- A comparison of unsupervised methods based on dichotomous data to identify clusters of airways symptoms: latent class analysis and partitioning around medoids methodsPublication . Amaral, Rita; Jacinto, Tiago; Pereira, Ana; Almeida, Rute; Fonseca, JoãoLatent class analysis (LCA) and partitioning around medoids (PAM) are popular data-driven methods for partitioning objects based on dichotomous data, remaining not clear which is better for large epidemiological datasets. Hence, we compared these methods in the identification of clusters of subjects with airways symptoms, using a large population-based data from the U.S. National Health and Nutrition Examination Surveys (NHANES).