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- A comparison of unsupervised methods based on dichotomous data to identify clusters of airways symptoms: latent class analysis and partitioning around medoids methodsPublication . Amaral, Rita; Jacinto, Tiago; Pereira, Ana; Almeida, Rute; Fonseca, JoãoLatent class analysis (LCA) and partitioning around medoids (PAM) are popular data-driven methods for partitioning objects based on dichotomous data, remaining not clear which is better for large epidemiological datasets. Hence, we compared these methods in the identification of clusters of subjects with airways symptoms, using a large population-based data from the U.S. National Health and Nutrition Examination Surveys (NHANES).