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- Diabetic neuropathy and oxidative stress: a systematic review focused on oxidative stress biomarkers analysisPublication . Cunha, Sofia; Nascimento, Ana Paula; Vieira, Mónica; Prudêncio, CristinaDiabetic neuropathy is a worldwide disease with great impact in modern society. Diabetes may lead to the overproduction of reactive oxygen species, resulting in an imbalance in body’s redox homeostasis. Oxidative stress is pointed as an important phenomenon associated with several disease states, including diabetic neuropathy.
- The effect of high concentrations of vitamin C on a H2O2 - oxidative stress induced yeast modelPublication . Costa, Ana Rita; Cunha, Sofia; Nascimento, Ana Paula; Vieira, Mónica; Prudêncio, CristinaNowadays, the ageing of population is conducting to a rise in the number of individuals with age-related illnesses, in which neurodegenerative diseases (ND) are included. Regardless of many variations in etiology and diverse mechanisms of cell injury, most of ND share high levels of oxidative stress, which have been highly referred not only as an underlying factor, but also as a feature. Thus, an actual challenge is to evaluate the role of antioxidants on oxidative stress states and evaluate the magnitude of possible therapeutic effects of these agents. In the present study, the toxic effect of hydrogen peroxide (H2O2) and the antioxidative function of vitamin C were investigated using Saccharomyces cerevisiae as a model. Results were achieved by exposing the yeast model to different concentrations of H2O2 and vitamin C, itself or combined, and colony forming units counting after 48 h incubation at 30ºC in Yeast Extract Peptone Dextrose agar plates. The results demonstrated that H2O2 exposure decreased yeast cells viability in a dose-dependent manner and that, at an optimal concentration, vitamin C was able to revert its effects. These results improved the understanding of the reversal effect of antioxidant treatment and, therefore, may be helpful on providing insights on a natural antioxidant-based therapy for ND.
- Book of abstracts 4th Meeting on Medicinal Biotechnology (4EBtM)Publication . Costa, Ana Rita; Dias, Ana Rita; Prudêncio, Cristina; Borges, Cristina; Teixeira, Dulce; Almeida, Joana; Vieira, Mónica; Coelho, Pedro; Ferraz, Ricardo; Cunha, SofiaThese meetings have been held once a year since 2015 and have played an important role as a point of contact among several professionals and students in Medicinal Biotechnology. Like the Medicinal Biotechnology field itself, these meetings have also been expanding, not only in the number of participants, but also in their geographical origin. Therefore, it is our goal to act as an interface between students and biotechnology companies/researchers, as well as to increasingly promote networking, projects and collaborations within this field for the upcoming years.
- Modulation of oxidative stress with Vitamin E in Sacharomyces cerevisiaePublication . Alves, M.; Cunha, Sofia; Costa, A.; Nascimento, Ana Paula; Vieira da Silva, Manuela; Prudêncio, CristinaNeurodegenerative diseases, such as Parkinson’s Disease or Alzheimer’s Disease, are characterized by the death of a subset of neurons over long periods of time.
- Book of abstracts of the III Encontro de Biotecnologia Medicinal/ I Iberian Congress on Medicinal BiotechnologyPublication . Costa, Ana Rita; Prudêncio, Cristina; Teixeira, Dulce; Almeida, Joana; Vieira, Mónica; Coelho, Pedro; Ferraz, Ricardo; Cunha, Sofia; Dias, Ana RitaEstes encontros de Biotecnologia Medicinal iniciaram-se em 2015 e sentimos que estamos a crescer, tal como a Biotecnologia Medicinal. Esta área da Biotecnologia tem ganho relevância, quer em empresas, quer a nível académico, criando interfaces entre a biologia molecular, a microbiologia e a química medicinal.
- Assessment of pain characteristics in patients of Clínica Médica Povo Portuense: 3 seasons studyPublication . Cunha, Sofia; Vieira, Mónica; Prudêncio, CristinaCurrently, most of the patients having chronic pain (CP) present neuropathic pain (NP). Therefore, the study of the main features of pain contributes to a better and more appropriate treatment. To study the duration and etiology of pain, associated pathologies (AP) and usual medication (UM) as well its socio-demographic characteristics (SDC); To assess pain location (PL), intensity, relief by medication and its effect on daily activities (DA); To determine the main features of NP.
- Evaluation of the bacterial activity of natural compoundsPublication . Costa, Miguel; Cunha, Sofia; Prudêncio, Cristina; Parente, E.; Vieira da Silva, ManuelaMedicinal plants with therapeutic properties are an important source of new biologically active compounds. They present great potential for therapeutics and prevention applications. The use of plant extracts and phytochemical products, both with known antimicrobial properties, is of great importance in the treatment of infectious diseases, where resveratrol, propolis and chamomile stand out
- Dermocosmética: qualidade na produção e análise comparativaPublication . Neves, Joana; Oliveira, Ana Isabel; Nascimento, Ana Paula; Cunha, Sofia; Nogueira, Lúcia; Silva, Manuel; Prudêncio, Cristina; Vieira, MónicaOs cosméticos podem ser utilizados na higiene pessoal ajudando a melhorar a aparência. Para a sua produção, é necessário o cumprimento de normas específicas que garantam a qualidade do produto, pelo que o design da estrutura onde estes são produzidos é um fator determinante.