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- Antiproliferative organic salts derived from betulinic acid: Disclosure of an ionic liquid selective against lung and liver cancer cellsPublication . Silva, Ana Teresa; Cerqueira, Maria João; Prudêncio, Cristina; Fernandes, Maria Helena; Costa-Rodrigues, João; Teixeira, Cátia; Gomes, Paula; Ferraz, RicardoIn the last few years, we have been witnessing an increasing interest in ionic liquids (ILs) and organic salts, given their potential applications in biological and pharmaceutical sciences. We report the synthesis and in vitro evaluation of novel organic salts combining betulinate, known for its anticancer properties, with antimalarial drugs, primaquine, chloroquine, and mepacrine, and also with the trihexyltetradecylphosphonium ([P6,6,6,14]) cation. The salts were screened for their in vitro activity against tumor lines HepG2 (liver), MG63 (osteosarcoma), T47D (breast), A459 (lung), and RKO (colon), and also on normal human fibroblasts. All betulinates prepared displayed antiproliferative properties, with the trihexyltetradecylphosphonium betulinate standing out for its higher selectivity. This unprecedented disclosure of a betulinic acid (BA)-derived IL with selective antitumor activity constitutes a relevant first step toward development of novel anticancer therapies based on BA-derived IL.
- Biotechnology and biochemistry laboratorial education through the SARS-CoV2 pandemic: challenges, truths and takeawaysPublication . Almeida, Joana; Pereira, Cassilda; Coelho, Pedro; Teixeira, Dulce; Louçano, Marta; Bento, C.; Cerqueira, Maria João; Prudêncio, Cristina; Ferraz, Ricardo; Vieira, MónicaIn early 2020, the COVID-19 pandemic forced the higher education institutions to adapt to a new form of teaching and learning, from presential to full remote, blended and hybrid environment.
- Book of Abstracts of 5th Meeting of Medicinal Biotechnology (5MBtM) and 2nd Iberian Congress on Medicinal BiotechnologyPublication . Sieiro, Carmen; Pereira, Cassilda; Prudêncio, Cristina; Oliveira, Daniela; Teixeira, Dulce; Barros, Eduarda; Almeida, Joana; Cerqueira, Maria João; Louçano, Marta; Vieira, Mónica; Coelho, Pedro; Ferraz, Ricardo