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- Diabetic neuropathy and oxidative stress: a systematic review focused on oxidative stress biomarkers analysisPublication . Cunha, Sofia; Nascimento, Ana Paula; Vieira, Mónica; Prudêncio, CristinaDiabetic neuropathy is a worldwide disease with great impact in modern society. Diabetes may lead to the overproduction of reactive oxygen species, resulting in an imbalance in body’s redox homeostasis. Oxidative stress is pointed as an important phenomenon associated with several disease states, including diabetic neuropathy.
- Satisfação profissional: um estudo com enfermeiros especialistas em enfermagem de reabilitaçãoPublication . Marques, Raquel Maria Dos Reis ; Pimenta, Rui; Nascimento, Ana PaulaEste estudo pretendeu analisar a satisfação profissional dos Enfermeiros Especialistas em Enfermagem de Reabilitação (EEER) e também averiguar se o exercício de cuidados de especialidade ou o exercício de cuidados gerais influencia a sua satisfação profissional. A satisfação profissional foi avaliada através da aplicação da “Escala de Avaliação da Satisfação no Trabalho dos Enfermeiros” a 306 profissionais de Enfermagem, especialistas em Enfermagem de Reabilitação. Foi realizado um estudo transversal analítico. Como instrumentos de análise estatística dos dados, recorreu-se à análise fatorial, ao coeficiente de correlação de Spearman e ao teste paramétrico t-student para amostras independentes. Os resultados mostram que os EEER se encontram ligeiramente insatisfeitos. Verificamos que os EEER que exercem cuidados gerais apresentam-se mais insatisfeitos do que os que exercem cuidados de especialidade.
- The effect of high concentrations of vitamin C on a H2O2 - oxidative stress induced yeast modelPublication . Costa, Ana Rita; Cunha, Sofia; Nascimento, Ana Paula; Vieira, Mónica; Prudêncio, CristinaNowadays, the ageing of population is conducting to a rise in the number of individuals with age-related illnesses, in which neurodegenerative diseases (ND) are included. Regardless of many variations in etiology and diverse mechanisms of cell injury, most of ND share high levels of oxidative stress, which have been highly referred not only as an underlying factor, but also as a feature. Thus, an actual challenge is to evaluate the role of antioxidants on oxidative stress states and evaluate the magnitude of possible therapeutic effects of these agents. In the present study, the toxic effect of hydrogen peroxide (H2O2) and the antioxidative function of vitamin C were investigated using Saccharomyces cerevisiae as a model. Results were achieved by exposing the yeast model to different concentrations of H2O2 and vitamin C, itself or combined, and colony forming units counting after 48 h incubation at 30ºC in Yeast Extract Peptone Dextrose agar plates. The results demonstrated that H2O2 exposure decreased yeast cells viability in a dose-dependent manner and that, at an optimal concentration, vitamin C was able to revert its effects. These results improved the understanding of the reversal effect of antioxidant treatment and, therefore, may be helpful on providing insights on a natural antioxidant-based therapy for ND.
- The use of statistics in real and simulated investigations performed by undergraduate health sciences' studentsPublication . Pimenta, Rui; Nascimento, Ana Paula; Vieira, Margarida; Costa, ElísioIn previous works, we evaluated the statistical reasoning ability acquired by health sciences’ students carrying out their final undergraduate project. We found that these students achieved a good level of statistical literacy and reasoning in descriptive statistics. However, concerning inferential statistics the students did not reach a similar level. Statistics educators therefore claim for more effective ways to learn statistics such as project based investigations. These can be simulated, based on previously supplied data, or real, based on data collected by the students themselves. In this work, we intend to evaluate and compare the statistical reasoning and thinking ability acquired by health sciences’ students when conducting both real and simulated investigations.
- Cluster analysis of noncommunicable diseases in PortugalPublication . Nascimento, Ana Paula; Prudêncio, Cristina; Vieira, Mónica; Pimenta, Rui; Bacelar-Nicolau, HelenaThe most common noncommunicable diseases, such as cardiovascular diseases, cancer or respiratory diseases, are a problem in global and national growth. The World Health Organization (WHO) considers it a priority to study the specific causes of these diseases for trend monitoring. The aim is to identify a hierarchy of clusters of Portuguese mortality by noncommunicable diseases using the ascending hierarchical classification methodology. The results identifying three clusters A, A2 and B2 of diseases are proposed for study. It is suggested that the risk factors and / or pathophysiological mechanisms that in a direct or indirect way may enhance the common development of the pathologies found in the clusters studied should be an object of priority study.
- Modulation of oxidative stress with Vitamin E in Sacharomyces cerevisiaePublication . Alves, M.; Cunha, Sofia; Costa, A.; Nascimento, Ana Paula; Vieira da Silva, Manuela; Prudêncio, CristinaNeurodegenerative diseases, such as Parkinson’s Disease or Alzheimer’s Disease, are characterized by the death of a subset of neurons over long periods of time.
- Dermocosmética: qualidade na produção e análise comparativaPublication . Neves, Joana; Oliveira, Ana Isabel; Nascimento, Ana Paula; Cunha, Sofia; Nogueira, Lúcia; Silva, Manuel; Prudêncio, Cristina; Vieira, MónicaOs cosméticos podem ser utilizados na higiene pessoal ajudando a melhorar a aparência. Para a sua produção, é necessário o cumprimento de normas específicas que garantam a qualidade do produto, pelo que o design da estrutura onde estes são produzidos é um fator determinante.