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- Diabetic neuropathy and oxidative stress: a systematic review focused on oxidative stress biomarkers analysisPublication . Cunha, Sofia; Nascimento, Ana Paula; Vieira, Mónica; Prudêncio, CristinaDiabetic neuropathy is a worldwide disease with great impact in modern society. Diabetes may lead to the overproduction of reactive oxygen species, resulting in an imbalance in body’s redox homeostasis. Oxidative stress is pointed as an important phenomenon associated with several disease states, including diabetic neuropathy.
- The effect of high concentrations of vitamin C on a H2O2 - oxidative stress induced yeast modelPublication . Costa, Ana Rita; Cunha, Sofia; Nascimento, Ana Paula; Vieira, Mónica; Prudêncio, CristinaNowadays, the ageing of population is conducting to a rise in the number of individuals with age-related illnesses, in which neurodegenerative diseases (ND) are included. Regardless of many variations in etiology and diverse mechanisms of cell injury, most of ND share high levels of oxidative stress, which have been highly referred not only as an underlying factor, but also as a feature. Thus, an actual challenge is to evaluate the role of antioxidants on oxidative stress states and evaluate the magnitude of possible therapeutic effects of these agents. In the present study, the toxic effect of hydrogen peroxide (H2O2) and the antioxidative function of vitamin C were investigated using Saccharomyces cerevisiae as a model. Results were achieved by exposing the yeast model to different concentrations of H2O2 and vitamin C, itself or combined, and colony forming units counting after 48 h incubation at 30ºC in Yeast Extract Peptone Dextrose agar plates. The results demonstrated that H2O2 exposure decreased yeast cells viability in a dose-dependent manner and that, at an optimal concentration, vitamin C was able to revert its effects. These results improved the understanding of the reversal effect of antioxidant treatment and, therefore, may be helpful on providing insights on a natural antioxidant-based therapy for ND.
- Modulation of oxidative stress with Vitamin E in Sacharomyces cerevisiaePublication . Alves, M.; Cunha, Sofia; Costa, A.; Nascimento, Ana Paula; Vieira da Silva, Manuela; Prudêncio, CristinaNeurodegenerative diseases, such as Parkinson’s Disease or Alzheimer’s Disease, are characterized by the death of a subset of neurons over long periods of time.
- Dermocosmética: qualidade na produção e análise comparativaPublication . Neves, Joana; Oliveira, Ana Isabel; Nascimento, Ana Paula; Cunha, Sofia; Nogueira, Lúcia; Silva, Manuel; Prudêncio, Cristina; Vieira, MónicaOs cosméticos podem ser utilizados na higiene pessoal ajudando a melhorar a aparência. Para a sua produção, é necessário o cumprimento de normas específicas que garantam a qualidade do produto, pelo que o design da estrutura onde estes são produzidos é um fator determinante.