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- Detection of CA19-9 using fluorescent polymer imprinted membranesPublication . Xu, Ana; Piloto, Ana Margarida L.(Introduction) The Carbohydrate antigen19-9 (CA19-9) is a biomarker widely used for the diagnosis and monitoring of various types of cancer, especially pancreatic cancer (PC). Molecularly Imprinted Polymers (MIPs) are synthetic materials with recognition sites molecularly designed to bind selectively to a target analyte, providing high specificity and sensitivity. In this work, the use of solid supports such as membranes, was used to imprint the MIPs, allowing the creation of robust and easy-to-manipulate biomimetic sensors for the precise and efficient detection of biomarkers, specifically CA19-9.
- Optical detection of CA19-9 protein using yellow quantum dots with molecularly imprinted polymersPublication . Xu, Ana; Piloto, Ana Margarida L.(Introduction) Biosensors are crucial for rapid and accurate diagnoses, vital for effective treatment strategies. ❖ Traditional immunoassays have susceptibility to instability and compromise the accuracy of the results. Molecularly imprinted polymers (MIP) are emerging as biomimetic sensors that offer stability, selectivity, and resistance to environmental variations. Quantum dots (QDs) have versatile optical detection probes, raising the sensitivity of detection methods. This work aims to create a biomimetic sensor for the detection of the biomarker CA19-9, associated with pancreatic cancer.