Browsing by Issue Date, starting with "2023-05-09"
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- Electrochemical chemically based sensors and emerging enzymatic biosensors for antidepressant drug detection: a reviewPublication . Caldevilla, Renato; Morais, Stephanie L.; Cruz, Agostinho; Delerue-Matos, Cristina; Moreira, Fernando; Pacheco, João G.; Santos, Marlene; Barroso, Maria FátimaMajor depressive disorder is a widespread condition with antidepressants as the main pharmacological treatment. However, some patients experience concerning adverse reactions or have an inadequate response to treatment. Analytical chromatographic techniques, among other techniques, are valuable tools for investigating medication complications, including those associated with antidepressants. Nevertheless, there is a growing need to address the limitations associated with these techniques. In recent years, electrochemical (bio)sensors have garnered significant attention due to their lower cost, portability, and precision. Electrochemical (bio)sensors can be used for various applications related to depression, such as monitoring the levels of antidepressants in biological and in environmental samples. They can provide accurate and rapid results, which could facilitate personalized treatment and improve patient outcomes. This state-of-the-art literature review aims to explore the latest advancements in the electrochemical detection of antidepressants. The review focuses on two types of electrochemical sensors: Chemically modified sensors and enzyme-based biosensors. The referred papers are carefully categorized according to their respective sensor type. The review examines the differences between the two sensing methods, highlights their unique features and limitations, and provides an in-depth analysis of each sensor.
- Vila do Conde como destino turístico: proposta de um roteiro para a sua promoção e divulgaçãoPublication . Silva, David Filipe Rodrigues de Azevedo e; Melo, CarlaVila do Conde, município localizado no litoral norte de Portugal, carateriza-se pela sua diversidade, uma vez que possui mar, rio, natureza e património. A cidade de José Régio é conhecida nacionalmente pela sua doçaria conventual, e internacionalmente, pela sua renda de bilro (recorde do Guiness). O turismo tem crescido substancialmente na cidade nos últimos anos, fruto da inserção de Vila do Conde na rota dos Caminhos de Santiago, da proximidade com a cidade do Porto e com o aeroporto internacional Francisco Sá Carneiro, e ainda, com o aparecimento de novos restaurantes (como por exemplo, o Le Villageois Restaurante) e unidades de alojamento (ex.: Pousada da Juventude de Vila do Conde). Prevê-se que este crescimento continue no futuro, e que a abertura de uma unidade hoteleira de 5 estrelas (prevista para o final de 2023) implantada no ex-libris da cidade, o Mosteiro de Santa Clara, venha a atrair novos segmentos de turistas, e a contribuir para a consolidação do concelho como destino turístico. O estágio em análise, que incluiu entre outras tarefas, a criação de um roteiro para a promoção e divulgação dos principais atrativos turísticos de Vila do Conde, revelou-se assim, de extrema importância, já que permitiu a aquisição de importantes competências.
- Tribological Behavior of Doped DLC Coatings in the Presence of Ionic Liquid Additive under Different Lubrication RegimesPublication . Sadeghi, Mohammadamin; Omiya, Takeru; Fernandes, Filipe; Vilhena, Luís; Ramalho, Amilcar; Ferreira, FábioDiamond-like carbon (DLC) coatings are widely used in industries that require high durability and wear resistance, and low friction. The unique characteristics of DLC coatings allow for the possibility of creating adsorption sites for lubricant additives through the doping process. In this study, the combined use of europium-doped diamond-like carbon (Eu-DLC), gadolinium-doped diamond-like carbon (Gd-DLC), and pure DLC coatings and an ionic liquid (IL) additive, namely, trihexyltetradecylphosphonium bis (2-ethylhexyl) phosphate [P66614] [DEHP], with a 1 wt.% concentration in polyalphaolefin (PAO) 8 as a base lubricant was investigated. Higher hardness, higher thin-film adhesion, a higher ratio of hardness to elastic modulus, and a higher plastic deformation resistance factor were achieved with the Gd-DLC coating. The CoF of the Gd-DLC coating paired with the IL was superior compared to the other pairs in all lubrication regimes, and the pure DLC coating had a better performance than the Eu-DLC coating. The wear could not be quantified due to the low wear on the surface of the DLC coatings. The friction reduction demonstrates that tribological systems combining Gd-DLC thin films with an IL can be a potential candidate for future research and development efforts to reduce friction and increase the efficiency of moving parts in internal combustion engines, for instance.