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- Psychotropic drugs and liver disease: a critical review of pharmacokinetics and liver toxicityPublication . Telles-Correia, Diogo; Barbosa, António; Cortez-Pinto, Helena; Campos, Carlos; Rocha, Nuno; Machado, SérgioThe liver is the organ by which the majority of substances are metabolized, including psychotropic drugs. There are several pharmacokinetic changes in end-stage liver disease that can interfere with the metabolization of psychotropic drugs.