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- ALC Neuroprotection through autophagy and ups acitivityPublication . Bravo, Joana; Cunha, Lídia; Fernandes, Sílvia; Binienda, Zbigniew; Summavielle, TeresaAcetyl–L-carnitine (ALC) has beneficial effects in neurodegenerative diseases and was shown to be protective against exposure to methamphetamine (METH) reducing mitochondrial dysfunction and oxidative stress. However, the mechanisms underlying ALC action are still unknown, limiting its putative therapeutic use.