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Browsing by Issue Date, starting with "2008-01"

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  • Estudo do Stress nos Técnicos de Radiologia
    Publication . Videira, Sara; Ventura, Sandra Rua
    O conceito de stress nem sempre foi consensual, no entanto, vários estudos têm documentado a relevância deste no contexto das diferentes profissões. O stress parece ser particularmente importante quando aplicado aos profissionais de saúde, estes estão frequentemente propensos ao burnout, termo que descreve o estado deexaustão prolongada e diminuição de interesse, especialmente em relação ao trabalho.
    2008-01Journal article Open access Show more
  • Voice parameters in children with Down syndrome
    Publication . Moura, Carla Pinto; Cunha, Luís Miguel; Vilarinho, Helena; Cunha, Maria João; Freitas, Diamantino; Palha, Miguel; Pueschel, Siegfried M.; Pais-Clemente, M.; Gonçalves, Maria João Moreira
    Down syndrome (DS) is the most frequent chromosomal disorder. Commonly, individuals with DS have difficulties with speech and show an unusual quality in the voice. Their phenotypic characteristics include general hypotonia and maxillary hypoplasia with relative macroglossia, and these contribute to particular acoustic alterations. Subjective perceptual and acoustic assessments of the voice (Praat-4.1 software) were performed in 66 children with DS, 36 boys and 30 girls, aged 3 to 8 years. These data were compared with those of an age-matched group of children from the general population. Perceptual evaluations showed significant differences in the group of children with DS. The voice of children with DS presented a lower fundamental frequency (F0) with elevated dispersion. The conjunction of frequencies for formants (F1 and F2) revealed a decreased distinction between the vowels, reflecting the loss of articulatory processing. The DS vocalic anatomical functional ratio represents the main distinctive parameter between the two groups studied, and it may be useful in conducting assessments.
    2008-01Research article Open access Show more
  • Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones
    Publication . Vale, Nuno; Collins, Margaret S.; Gut, Jiri; Ferraz, Ricardo; Rosenthal, Philip J.; Cushion, Melanie T.; Moreira, Rui; Gomes, Paula
    A series of primaquine-derived imidazolidin-4-ones were screened for their in vitro activity against Pneumocystis carinii and Plasmodium falciparum W2 strain. Most compounds were active against P. carinii above 10 lg/mL and displayed slight to marked activity. The imidazolidin-4-ones most active against P. carinii were also those most active antiplasmodial agents, in the lM range. One of the tested imidazolidin-4-ones was slightly more active than the parent primaquine and may represent a lead com pound for the development of novel anti-P. carinii 8-aminoquinolines with increased stability and resistance to metabolic inactivation.
    2008-01-15Journal article Open access Show more