Percorrer por autor "Vieira, Catarina"
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- Assessment of patient knowledge on medications for irritable bowel syndromePublication . Ferreira, Maria Inês; Vieira, Catarina; Oliveira, Ana Isabel; Oliveira, Rita F.; Ferraz Oliveira, RitaIrritable Bowel Syndrome (IBS) is a multifactorial gastrointestinal disorder that may involve genetic factors, as well as physiological and psychological responses. It affects approximately 10-20% of the world’s population. Although not fatal, it has a significant impact on the quality of life. Knowledge about treatment is essential, as it plays a crucial role in symptom relief [1,2]. To assess patients’ knowledge about IBS medication and emergency medication administration. Observational, descriptive, cross-sectional study using a non-probabilistic convenience sample. The pilot study included 22 patients at Padre Américo Hospital, Vale do Sousa, through an anonymous telephone survey, including medication name, action, dosage, duration, precautions, side effects, interactions, storage, and SOS use. Approved by the hospital ethics committee, participants signed informed consent and were anonymously identified using numerical codes. The sample was predominantly female (72.7%) with a mean age of 50 years. The majority (72.7%) knew what to administer and how to administer emergency medication (antidiarrheal, antiflatulents, laxatives, antispasmodics, benzodiazepines), and 63.6% demonstrated adequate knowledge about the diet that worsens symptoms. Significant gaps were found in knowledge regarding dosage, precautions, adverse reactions, contraindication, and medication storage. The present study helped identify existing gaps in patients’ knowledge, demonstrating that it can be a useful tool for assessing awareness of therapeutic interventions in larger patient samples with this condition. Health literacy is crucial to increasing medication adherence and safety. Limitations include the small sample size and the homogeneity of the participants. Future perspectives should include larger and more diverse samples.
- Mercury, cadmium, lead and arsenic levels in three pelagic fish species from the Atlantic Ocean: intra- and inter-specific variability and human health risks for consumptionPublication . Vieira, Catarina; Morais, S.; Ramos, Sandra; Delerue-Matos, Cristina; Oliveira, M. Beatriz P. P.Three commonly consumed and commercially valuable fish species (sardine, chub and horse mackerel) were collected from the Northeast and Eastern Central Atlantic Ocean in Portuguese waters during one year. Mercury, cadmium, lead and arsenic amounts were determined in muscles using graphite furnace and cold vapour atomic absorption spectrometry. Maximum mean levels of mercury (0.1715 ± 0.0857 mg/kg, ww) and arsenic (1.139 ± 0.350 mg/kg, ww) were detected in horse mackerel. The higher mean amounts of cadmium (0.0084 ± 0.0036 mg/kg, ww) and lead (0.0379 ± 0.0303 mg/kg, ww) were determined in chub mackerel and in sardine, respectively. Intra- and inter-specific variability of metals bioaccumulation was statistically assessed and species and length revealed to be the major influencing biometric factors, in particular for mercury and arsenic. Muscles present metal concentrations below the tolerable limits considered by European Commission Regulation and Food and Agriculture Organization of the United Nations/World Health Organization (FAO/WHO). However, estimation of non-carcinogenic and carcinogenic health risks by the target hazard quotient and target carcinogenic risk, established by the US Environmental Protection Agency, suggests that these species must be eaten in moderation due to possible hazard and carcinogenic risks derived from arsenic (in all analyzed species) and mercury ingestion (in horse and chub mackerel species).
- Nephrotoxicity effects of the wood preservative chromium copper arsenate on mice: histopathological and quantitative approachesPublication . Matos, Rita Cerejeira; Vieira, Catarina; Morais, Simone; Pereira, Maria de Lourdes; Pedrosa, J.Chromium copper arsenate(CCA)was used for the protection of wood building material suntil the restriction by EPA in2002. During a short period of time 14–24h,a comparative nephrotoxicity study was performed regarding the effects of CCA and its compounds per se. Histopathological and histochemical features were correlated with the concentration of the total arsenic and chromium in mice kidney. Animals were subcutaneously injected with CCA(7.2mg/kg arsenic and 10.2mg/kg chromium per body weight), CrO3 (10.2 mg/kg),As2O5 (7.2 mg/kg)andNaCl(0.9%) per se. The histopathological examination of the renal sections evidenced acute tubular necrosis in the groups of animals exposed to CCA(in both periods of time). Although the same contents of pentavalent arsenic and hexavalent chromium were injected in treated animals with CCA and with the prepared solutions of As2O5 and CrO3, the arsenic concentration on kidneys of CCA-exposed animals was much higher than those in animals exposed to As2O5 (32- and28-fold higher at 14 and 24h,respectively). However,the elimination of chromium seems to occur similarly in the kidneys of animals treated with CCA and CrO3 per se. Interactions among the components of CCA result in a marked decrease of the ability of kidney to eliminate simultaneously both analytes.The nephrotoxicity of CCA was higher than its components per se, evidencing a possible synergetic effect.
- Nephrotoxicity of CCA-treated wood: a comparative study with As2O5 and CrO3 on micePublication . Matos, Rita Cerejeira; Vieira, Catarina; Morais, Simone; Pereira, Maria de Lourdes; Jesus, Júlio Pedrosa deThe purpose of this work was to assess the acute toxicity on male mice to a chromated copper arsenate (CCA) solution, a widespread wood preservative used in building industry until 2002. Animals were subcutaneously injected with CCA (7.2 mg/kg arsenic and 10.2 mg/kg chromium per body weight), CrO3 (10.2 mg/kg), As2O5 (7.2 mg/kg) and NaCl (0.9%) per se, during 48 h and 96 h, for histopathology, histochemistry, chromium and arsenic analysis. The results showed some histopathological changes within renal tubules lumen of CCA exposed animals (during 48 h, and 96 h), and CrO3 (for the period of 96 h). Furthermore, the renal levels of arsenic and chromium in treated animals were statistically more evident than controls. Although, the same contents of pentavalent arsenic and hexavalent chromium were injected into treated animals with CCA and with the prepared solutions of As2O5 and CrO3, a different distribution of the pattern of these compounds was observed in kidneys.
- Toxicity of chromated copper arsenate: a study in micePublication . Matos, Rita Cerejeira; Vieira, Catarina; Morais, S.; Pereira, Maria de Lourdes; Pedrosa, J.Chromated copper arsenate (CCA) was widespread used as a chemical wood preservative with application in the construction of playground equipment, fences, jetties, and naval. Environmental protection agency (EPA) had limited the use of CCA-treated wood on 2002, due to probable implications on both human and environmental health. Although this fact, several industries pursue the use of this product within their manufactories. In addition, the durability of this wood for 60 years, makes these treated products an hazard to the public health. In the present work, studies were explored exposing mice to CCA, during 14, 24, 48, and 96 h for the assessment of acute toxicity of CCA. Kidney and liver were removed, prepared for histology and for metalloid, and copper content evaluation by high resolution inductively coupled plasma mass spectroscopy. The histological results evidenced apparently normal structures for control animals and group exposed to As2O5. On the contrary, the renal sections of the animals treated with CCA revealed epithelium cells desquamation, hyaline, and granular casts in renal tubules lumen. Furthermore, high levels of arsenic were detected in the kidney of animals treated with CCA over 14 and 48 h, being significantly greater than controls. Although this approach underlines the potential hazard of CCA on some vital organs, further testing may be required to establish the impacts on other functions.