Browsing by Author "Silva, Carina"
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- Do firms internationalize because they are profitable or are firms profitable because they internationalize? Assessing the causality between internationalization and profitability in new venturesPublication . Mendes, Telma; González-Loureiro, Miguel; Braga, Vítor; Silva, CarinaInternational business (IB) theories, including the Uppsala model and the International Entrepreneurship (IE) perspective, have provided explanations linking the level of the firm’s international commitment to organizational performance and found a non-linear relationship. However, causality in that relationship is still a veiled story. The aim of this study is to explore how the organizational age at the time of the first international market entry can change the direction of causality in the binomial internationalization-profitability. We add arguments based upon on the earliness of internationalization (how soon after inception a venture becomes an international player) to suggest a more complex relationship in which financial performance provides feedback on the implementation of internationalization strategies in the form of resources, particularly in firms that start internationalizing at a later stage. This feedback generates both the knowledge and the slack resources needed to support an adaptative feedback during the post-internationalization process. Using the most up-to-date technique in structural equation modeling for testing causality, we performed a multigroup analysis investigating the long-term rather than shortterm causal associations between international commitment and profitability in a longitudinal data set of 1,258 new ventures over five years of post-internationalization. Our findings showed that past profits positively contribute to future internationalization attempts in late internationals, but neither that causality nor the reverse were proven for early internationalizing firms. This cross-lagged evidence, therefore, supports the need to extend IB theories by considering financial performance as an antecedent and not just an outcome of the degree of internationalization.
- Do it or not? Explaining the complexity of decision-making processes for Industry 4.0 adoption in international SMEsPublication . Mendes, Telma; González-Loureiro, Miguel; Braga, Vítor; Silva, CarinaThe adoption of Industry 4.0 (I4.0) in small and medium-sized enterprises (SMEs) often rests on its positive evaluation from managers, decision-makers, and entrepreneurs. Because of the mixed outcomes attainable through the SMEs’ openness to disruptive changes, managers must weigh the beneficial aspects of I4.0 against the complexities, challenges, and drawbacks coming from its implementation. Drawing upon the tenets of the dual-process theory (DPT), this study highlights the cognitive configurations leading to managerial willingness (or reluctance) to adopt I4.0. This is done by investigating perceptions about the international markets in terms of risk and uncertainty, and by assessing organizational stimuli to openness, such as the explorative and exploitative orientations (i.e., ambidexterity), in combination with decision-makers’ cognitive systems. To shed further light on observed heterogenous outcomes, this study explores the managerial willingness (or reluctance) towards I4.0 adoption among 157 managers working in international SMEs. The results of combined Partial Least Squares Structural Equation Modeling (PLS-SEM) and fuzzy-set Qualitative Comparative Analysis (fsQCA) outline different decisional paths associated with willingness and reluctance to adopt I4.0 for internationalization. This empirical evidence, therefore, contributes to the “human side of I4.0” by providing fruitful implications about cognitive configurations of decision-makers in international SMEs concerning I4.0 practices.
- Looking back and looking forward: A multidisciplinary review of the speed of internationalization and future research directionsPublication . Mendes, Telma; González-Loureiro, Miguel; Braga, Vítor; Silva, CarinaObjectives: An increasing amount of research on the speed of internationalization has shown that this concept has found application across multiple contexts. However, this straddling of multidisciplinary domains fragments the academic understanding on the topic. Considering the growing interest in the speed of internationalization, this study seeks to provide an overview of the trajectory and evolution of the research field. Theoretical Framework: Building upon the review of 200 articles published in Web of Science and Scopus indexed journals, this article develops a context-specific research agenda, whereas discloses the main theoretical approaches used so far. Method: We combined a Correspondence Analysis (CA) along with a Delphi study of prolific authors and practitioners working on the speed of internationalization, we provide a multidisciplinary academic literature. Results/Implications: Our findings offer a holistic picture of the current scholarly research, outlining its key theoretical approaches, research themes, levels of research, and potential areas for future development on this topic.
- New CTX-M group conferring β-Lactam resistance: A compendium of phylogenetic insights from biochemical, molecular, and structural biologyPublication . Mendonça, Jacinta; Guedes, Carla; Silva, Carina; Sá, Sara; Oliveira, Marco; Accioly, Gustavo; Baylina, Pilar; Barata, Pedro; Pereira, Cláudia; Fernandes, RubenThe production of extended-spectrum β-lactamases (ESBLs) is the main defense mechanism found in Gram negative bacteria. Among all the ESBLs, the CTX-M enzymes appear as the most efficient in terms of dissemination in different epidemiological contexts. CTX-M enzymes exhibit a striking plasticity, with a large number of allelic variants distributed in several sublineages, which can be associated with functional heterogeneity of clinical relevance. This observational analytical study provides an update of this family, currently with more than 200 variants described, from a phylogenetic, molecular, and structural point of view through homology in amino acid sequences. Our data, combined with described literature, provide phylogenetic and structural evidence of a new group. Thus, herein, we propose six groups among CTX-M enzymes: the already stablished CTX-M-1, CTX-M-2, CTX-M-8, CTX-M-9, and CTX-M-25 clusters, as well as CTX-M-151 as the new cluster.
- On causality between sucessful internationalization and profitability: The case of the moderating effect of earliness in new venturesPublication . Mendes, Telma; González-Loureiro, Miguel; Silva, CarinaObjectives: We aim to explore whether the earliness of internationalization can change the direction of causality in the binomial internationalization-profitability. Theoretical Framework: The main theoretical explanation lies at the speed of the learning advantages of newness to address the contingent uncertainty of the (lack) of knowledge of the new international market, combining the Uppsala-Model and the International Entrepreneurship theories. Method: We performed a multigroup analysis using the most up-to-date technique among the available structural equation cross-lagged models for testing causality under the impulse-response approach. This enables the investigation of the long-term rather than the short-term Granger- Sims’ causal effects in a longitudinal data set of 1,258 new ventures over five years after the first international market entry. Results/Implications: Earliness of internationalization can be a key to understand both the sign and the direction of causality and its persistence over time. We augment the Uppsala Model with the causality of these relationships. For practitioners, they should know that the organizational time to go international can be a source of only temporary but not persistent advantages for early entrants.
- Oxidative stress genes involved in the virulence-dependent susceptibility to antibiotics in Pseudomonas aeruginosaPublication . Coelho, Pedro Barata; Fernandes, Ruben; Silva, Carina; Oliveira, Marco; Veiga, Marlene; Sá, Sara; Vieira, André; Guedes, Carla; Baylina, PilarPseudomonas aeruginosa is a Gram-negative opportunistic pathogen which rarely causes disease in healthy people. P. aeruginosa, in particular strain PAO1 is also a biological model for studying virulence and bacterial social traits, such as quorum sensing, SOS response among other. Antibiotic response is dependent, among several other factors, to the response to environmental stress conditions. The present study aims to understand the role of 10 PAO1 oxidative gene mutants in the response to antibiotic stress in elastase, protease and pyocyanin-dependent virulence factors. PAO1 was stressed to several antibiotics (penicilins, cephalosporins, macrolides, and quinolones), and the virulence proteins were measured by means of spectroscopic methods. Viability was measured by means of Erythrosin B. PAO1 GGT, GLO1, RubA2, GSH A mutants were the most susceptible to the production of virulence-dependent factors.
- Phylogenetic Insights of β-lactam resistance of the CTX-M familyPublication . Coelho, Pedro Barata; Mendonça, Jacinta; Silva, Carina; Baylina, Pilar; Fernandes, Ruben; Guedes, CarlaBacterial resistance is a major public health concern, particularly against β-lactam antibiotics, one of the most widely used antibacterial drugs. The production of extended-spectrum β-lactamases (ESBLs) is the main defense mechanism found in Gram negative bacteria. Among all the ESBLs, the CTX-M enzymes appear as the most efficient in terms of diffusion in different epidemiological contexts, outnumbering the others. Originated in chromosomal genes of Klyvera spp., the blaCTX-M genes have become associated with mobile genetic elements, such as plasmids, that have mediated inter-replication and dissemination. CTX-M enzymes exhibit a striking plasticity, with a large number of allelic variants belonging to several sub-lineages, which can be associated with functional heterogeneity of clinical relevance. This observational analytical study provides an update of this family, currently with more than 200 variants described, from a phylogenetic, molecular and structural point of view through homology in amino acid sequences. There are currently 6 defined clusters (CTX-M-1, CTX-M-2, CTX-M-8, CTX-M-9, CTX-M-25 and CTX-M-151), with the domains CTX -M-1 and CTX-M-9 presenting subgroups, composed mainly of variants identified as hybrids between them (particularly between CTX-M-14 and CTX-M-15).
- The ‘extra’ sparkle in higher education Institutions: Exploring staff perceptions towards corporate volunteeringPublication . Silva, Carina; Mendes, Telma; Ferreira, Marisa R.; Faria, TatianaThe analysis of barriers to volunteering and the intraorganizational conditions that can promote or hinder employee engagement in volunteer programs are important for researchers and practitioners. Despite the relevance of these topics, they remain unexplored in the context of Higher Education Institutions (HEIs), especially from the staff perspective. This represents an important theoretical gap, as HEIs are institutions that act in the public interest and represent the ideal context for spreading the culture of corporate volunteering due to their potential to connect theory to practice. Therefore, this study aims to explore how intraorganizational support moderates the relationship between both motivations and barriers to volunteering with the personal/impersonal outcomes of participating in these activities. The research is based on a sample of 155 public HEI employees obtained from the Northern Euro-region of Portugal/Galicia. The results of the partial least squares structural equation modeling (PLS-SEM) suggest that motivations to volunteer were positively associated with personal/impersonal outcomes stemming from these activities, while barriers to volunteering were negatively related. When testing the moderating effects, we found that HEI intraorganizational support weakened (strengthened) the positive (negative) relationship between motivations (barriers) to volunteer and the personal/impersonal outcomes stemming from volunteer activities. Overall, this empirical evidence allows us to understand both motivations and barriers to volunteering, as well as how intraorganizational conditions discourage participation in volunteering.
- The earlier the better? A microfoundational perspective of international explorative and exploitative capabilities in the transition of SMEs to Industry 4.0Publication . Mendes, Telma; González-Loureiro, Miguel; Braga, Vítor; Silva, CarinaThe international exploration-exploitation dichotomy is used in this study to expand on the resource-based view (RBV) and gain a deeper understanding of how these two distinct capabilities affect the adoption of I4.0 in small and medium-sized businesses (SMEs). We investigate managers' cognitive systems as a crucial microfoundation for the international organizational ambidexterity (i.e., exploration-exploitation), given that both managerial cognition and microfoundations perspective are underdeveloped and undertheorized. The study shows that managerial cognition is a crucial microfoundation of international organizational ambidexterity in the context of I4.0 adoption by using structural equation modeling on a sample of 116 Portuguese international SMEs. The findings also reveal neither international exploration nor exploitation has succeeded in creating new opportunities for the application of a technology-based model in SMEs internationalizing earlier. However, a post-hoc analysis revealed that under early internationalization, less (more) experienced SMEs benefit from international exploration (exploitation) to implement I4.0 technologies. This study concludes with implications and future research avenues.
- The history and applications of phage therapy in Pseudomonas aeruginosaPublication . Silva, Carina; Sá, Sara; Guedes, Carla; Oliveira, Carla; Lima, Cláudio; Oliveira, Marco; Mendes, João; Novais, Gonçalo; Baylina, Pilar; Fernandes, RúbenThe Pseudomonas aeruginosa is one of the bacteria that cause serious infections due to resistance to many antibiotics can be fatal in severe cases. Antimicrobial resistance is a global public health concern. To solve this problem, interest in phage therapy has revived; some studies are being developed to try to prove the effectiveness of this therapy. Thus, in this opinion article, several historical aspects are addressed as well some applications of phage therapy against P. aeruginosa.