Percorrer por autor "Pimentel, Francisco"
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- Complexity of the therapeutic regimen in older adults with cancer: associated factorsPublication . Oliveira, Rita F.; Oliveira, Ana I.; Cruz. Agostinho; Ribeiro, Oscar; Afreixo, Vera; Pimentel, Francisco; Cruz, Agostinho; Ferraz Oliveira, Rita; Oliveira, Ana IsabelPopulation aging is a worldwide phenomenon and is often associated with multimorbidity and polypharmacy. Complex medication regimens are common among older adults and contribute to the occurrence of harmful health outcomes. Age is one of the main risk factors for cancer. This study aimed to determine and characterize the therapeutic complexity in older patients with cancer, and analyze the factors associated with high complexity and the impact of the oncological context. A cross-sectional study with patients aged ≥65 years with cancer was conducted in three hospitals in northern Portugal. Data collection was obtained using self-reports. The medication regimen complexity was assessed using the Medication Regimen Complexity Index (MRCI). Descriptive and association statistical analysis were performed. Logistic, linear, simple and multiple regression analysis were conducted, with and without automatic variable selection. A total of 552 patients were included (median age, 71; IQR, 68–76). The mean MRCI before the oncological context was 18.67 (SD 12.60) and 27.39 (SD 16.67) after the oncological context, presenting a statistically significant difference in the values obtained (p < 0.001). An elevated complexity was significantly associated with polypharmacy, chronic diseases and with the administration of high-risk medications (p < 0.05). High MRCI values showed a relationship with the occurrence of potential drug interactions (p < 0.001). There was no relationship with the existence of cardiac risk comorbidity. This study demonstrated the existence of high therapeutic complexity in older patients with cancer, suggesting the need for intervention to prevent medication-related problems in this vulnerable population.
- Polypharmacy and drug interactions in older patients with cancer receiving chemotherapy: associated factorsPublication . Ferraz Oliveira, Rita; Oliveira, Ana Isabel; Cruz, Agostinho; Ribeiro, Oscar; Afreixo, Vera; Pimentel, FranciscoPolypharmacy in older adults with cancer receiving chemotherapy leads to increased risks of drug interactions, translating in potential hazardous health outcomes. This study aims to assess the prevalence of polypharmacy, drug–drug interactions (DDIs), and severe-drug interactions (SDIs) in older patients with cancer. Antineoplastic agents (ANAs) involvement and possible risk contexts (comorbidities with cardiac risk, and high-risk medications) were also analysed. ents (ANAs); it was conducted in three hospitals from the north of Portugal. Data collection was obtained using self-reports and medical records. DDIs were identifed and classifed using Micromedex® software. Descriptive and association analyze statistics were performed. Statistical hypothesis tests with p value less than 0.05 were considered signifcant. All statistical procedures and analysis were performed with R version 4.1.3. We enrolled 552 patients. Polypharmacy prevalence was 88.40%; 76.45% and 56.16% of the patients presented with DDIs and SDIs, respectively. SDIs with ANAs were found in 21.20% of the patients. High-risk medications were associated with a higher risk of polypharmacy, DDIs, and SDIs. Polypharmacy and DDIs were higher in patients with hypertension or diabetes. SDIs were higher in patients with diabetes. Polypharmacy, potential DDIs and SDIs were highly prevalent in older adults with cancer. A careful review of the medication administered is necessary to decrease it. These fndings warrant further research to optimize medication in this population and decrease problems related to medication, which may lead to emergency room visits and hospitalisations, compromising patient safety and/or ongoing treatments.
- Polypharmacy in older patients with cancerPublication . Ferraz Oliveira, Rita; Afreixo, Vera; Santos, João; Mota, Priscilla; Cruz, Agostinho; Pimentel, FranciscoPolypharmacy is associated with drug–drug interactions, adverse drug events, hospitalization, increased mortality and rising costs. Older cancer patients are potentially vulnerable to polypharmacy because cancer treatment often involves exposure to chemotherapy and other adjunctive or supportive medication.
- Qualidade de vida em doentes com melanoma cutâneo maligno das extremidades submetidos a perfusão isolada dos membros – estudo longitudinalPublication . Baeta, Cristina; Narciso, Jorge; Amaral, Rita; Ribeiro, Matilde; Araújo, António; Pimentel, FranciscoMelanoma cutâneo maligno (MM) pode ser considerado uma doença crónica, porque a incidência está a aumentar e a mortalidade a diminuir. A Perfusão Isolada dos Membros (PIM) é uma técnica/terapêutica invasiva que permite aos doentes com MM disseminado/volumoso/irressecável nas extremidades evitarem amputação e regredirem estádio da doença. O interesse da comunidade clínica/científica na Qualidade de Vida (QdV) em doentes oncológicos tem aumentado.