Browsing by Author "Lopes, Maria Inês Dias"
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- Atividade antimicrobiana de compostos flavonoides diméricosPublication . Lopes, Maria Inês Dias; Cerqueira, Maria de Fátima Araújo Magalhães; Medeiros, Rui; Campos, Carla Manuela Moutinho SilvaPlantas do género Arrabidaea são utilizadas na medicina popular (1). Estudos mostraram o efeito de flavonoides diméricos obtidos de Arrabidaea brachypoda contra protozoários da família Trypanosomatidae (1,2). Neste trabalho foi avaliada a atividade antimicrobiana de um extrato hidroetanólico (RAB), e da sua fração apolar obtida com diclorometano (RAB-DCM) e de três flavonoides diméricos – braquidina (Br) A, B e C, isolados desta fração. Todos inibiram o crescimento de Staphylococcus aureus sensíveis à meticilina (MSSA) usados: ATCC 29213 e V459. Nenhum foi ativo contra as leveduras testadas (Candida albicans, C. krusei e Cryptococcus neoformans) ou bactérias Gram-negativas (Escherichia coli). Br C foi a mais ativa em S. aureus ATCC 29212 (Concentração Inibitória Mínima – CIM - 12,0 μM) e a Concentração Mínima Letal (CML) indicou um efeito bacteriostático. O composto Br C provocou uma diminuição significativa dos halos de DNase e uma redução de 90% na atividade da catalase à concentração de 1/2 MIC. A atividade anti-inflamatória mostrou que o extrato RAB-DCM inibiu a produção de óxido nítrico por macrófagos RAW264.7 estimulados com LPS. Quanto ao efeito tóxico contra fibroblastos humanos, nenhum composto usado afetou significativamente a viabilidade celular. Os resultados deste trabalho destacam a potencial atividade antimicrobiana da braquidina C.
- Literacy to better understand the invisible world: Intervention in a children's communityPublication . Lopes, Maria Inês Dias; Oliveira, Ana Catarina Caetano; Pinho, Catarina Vaz; Carvalho, Tiago Monteiro; Lamas, Maria Céu; Mota, Sandra; Sousa, MariaHealth promotion and education aims to provide and develop strategies for the seizure of information by the individual, with consequent change in attitudes and behaviours. In this context, and with a view to reducing risk factors associated with infectious diseases, preventive measures should be adopted daily. Given that children are aware of the hygiene care importance but do not always have access to information about it, an intervention on this topic was carried out with a group of 10 children with an average age of 8 years old, with the goal of motivating participants to perform hygiene acts. The activity took place in a virtual room, on the Zoom/Colibri Platform, using Microsoft® PowerPoint and EaseUS Video Editor®, and was based on three sequential steps: (1) introduction of fundamental concepts; (2) exploration of the main groups of microorganisms and diseases; (3) multiple choice games and crossword puzzles. During the session, attention and interest in the contents were remarkable through the children's participation. In the games, they demonstrated excellent responsiveness and willingness to interact with all players. This approach, with several teaching–learning methodologies, proved to be enriching and allowed the acquisition of transversal and specific skills in several areas. This intervention promoted physical and emotional health in children, which follows a fundamental line to form sustainable societies since the children of today are the adults of the future.
- The power of the invisible beings: activities to raise awareness within children communitiesPublication . Lopes, Maria Inês Dias; Oliveira, Ana Catarina Caetano; Pinho, Catarina Vaz; Carvalho, Tiago Monteiro; Lamas, Maria Céu; Mota, Sandra; Amorim, ManuelaHealth promotion and education is especially important during childhood. Considering that children know the main hygiene care, but do not always have information regarding their importance, an intervention on this theme was carried out with a group of 10 children with an average age of 8 years, which aimed to motivate participants to perform hygiene acts. The activity was based on three sequential steps: introduction of fundamental concepts; exploration of the main groups of microorganisms and diseases; multiple choice games and crossword puzzles. During the session, attention and interest in the contents were notable, through the participation of the children. In the games, they demonstrated an excellent responsiveness and willingness to interact with all players. This intervention addressing various teaching-learning methodologies proved to be enriching and allowed the acquired transversal and specific skills to be acquired in several areas.