Browsing by Author "Lattari, Eduardo"
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- Aerobic Exercise Does Not Predict Brain Derived Neurotrophic Factor And Cortisol Alterations in Depressed PatientsPublication . Lamego, Murilo Khede; Souza Moura, Antonio Marcos de; Paes, Flávia; Rocha, Nuno; de Sá Filho, Alberto Souza; Lattari, Eduardo; Rimes, Ridson; Manochio, João; Budde, Henning; Wegner, Mirko; Mura, Gioia; Arias-Carrión, Oscar; Yuan, Ti-Fei; Nardi, Antonio Egidio; Machado, SergioThe pathophysiology of depression is related to neurobiological changes that occur in the monoamine system, hypothalamic-pituitary-adrenal axis, neurogenesis system and the neuroimmune system. In recent years, there has been a growing interest in the research of the effects of exercise on brain function, with a special focus on its effects on brainderived neurotrophic factor (BDNF), cortisol and other biomarkers. Thus, the aim of this study is to present a review investigating the acute and chronic effects of aerobic exercise on BDNF and cortisol levels in individuals with depression. It was not possible to establish an interaction between aerobic exercise and concentration of BDNF and cortisol, which may actually be the result of the divergence of methods, such as type of exercises, duration of the sessions, and prescribed intensity and frequency of sessions.
- Aerobic exercise reduces anxiety symptoms and improves fitness in patients with panic disorderPublication . Lamego, Murilo Khede; Lattari, Eduardo; Sá Filho, Alberto Souza de; Paes, Flávia; Mascarenhas Jr., Jarbas; Maranhão Neto, Geraldo; Oliveira, Aldair José de; Campos, Carlos; Rocha, Nuno; Nardi, Antonio E.; Machado, SergioTo investigate the effects of a regularly repeated aerobic exercise series on anxiety and maximum oxygen consumption (VO2max) in Panic Disorder patients. METHODS: Ten previously sedentary female subjects diagnosed with Panic Disorder performed 36 sessions of aerobic exercise (at 70 to 75% of VO2max), 3 times per week during 12 weeks. A cardiopulmonary evaluation (ergospirometry test) was used to set the intensity of training as well as to establish baseline and post-training VO2max parameters. The assessment of anxiety symptoms was performed at baseline, at the end of the 6th and 12th weeks, using the Trait Anxiety Inventory (STAI-T) and State Anxiety Inventory (STAI-S), and the Subjective Units of Distress Scale (SUDS) questionnaires. One-way ANOVA for repeated measurements (at 3 moments: Baseline, 6th week (mid-training) and 12th week (post-training) was used to compare the evolution of the questionnaires; the Bonferroni post hoc test was applied to identify differences between moments. A dependent t-test was performed for measures of VO2max. RESULTS: Compared to baseline, (a) STAI-T showed significant anxiety reductions at mid- and post-training moments; (b) STAI-S and SUDS recorded anxiety reductions only at Post-training; (c) VO2max showed a significant improvement at Post-training. CONCLUSION: This protocol promoted beneficial effects on cardiorespiratory fitness and anxiety levels of Panic Disorder patients.
- Can transcranial direct current stimulation improve the resistance strength and decrease the rating perceived scale in recreational weight-training experience?Publication . Lattari, Eduardo; Andrade, Maria L; Filho, Alberto S; Moura, Antônio M; Neto, Geraldo M; Silva, Júlio G; Rocha, Nuno; Yuan, Ti-Fei; Arias-Carrión, Oscar; Machado, SérgioLattari, E, Andrade, ML, Filho, AS, Moura, AM, Neto, GM, Silva, JG, Rocha, NB, Yuan, T-F, Arias-Carrión, O, and Machado, S. Can transcranial direct current stimulation improve the resistance strength and decrease the rating perceived scale in recreational weight-training experience? J Strength Cond Res 30(12): 3381-3387, 2016-The goal of this study was to evaluate the acute efficacy of anodic transcranial direct current stimulation on the total volume of repetitions and perceived exertion in recreationally trained individuals in strength. The sample consisted of 10 participants trained in exercise against resistance for at least 3 months. Participants underwent elbow flexion exercise at barbell with a specific load of 10 repetition maximum (10RM), responded immediately after the OMNI-RES scale, and were stimulated for 20 minutes with a tDSC protocol (2 mA), depending on randomization. After applying the tDSC, subjects were again subjected to perform elbow flexion with 10RM load and, soon after, again responded to OMNI-RES scale. All subjects underwent the 3 experimental conditions of the study, c-tDSC, a-tDSC, and sham-tDSC, which were randomized. A range of 48-72 hours was allowed between each assessment visit. An interaction to condition and time (F = 52.395; p ≤ 0.001) has shown that repetitions completed after anodic condition were higher compared with the other conditions in the postsession. In relation to perceived exertion, verified by OMNI-RES scale, 2-way analysis of variance for repeated measures showed an interaction between condition and time (F = 28.445; p ≤ 0.001), where the perceived exertion was decreased after the a-tDSC condition and increased after the c-tDSC condition. In strict terms of performance, it seems to be beneficial to attend a session of 20 minutes a-tDSC, when strength training practitioners can no longer support high-volume training and have increased responses in the perceived exertion.
- Can transcranial direct current stimulation on the dorsolateral prefrontal cortex improves balance and functional mobility in Parkinson’s disease?Publication . Lattari, Eduardo; Costa, Samara Sezana; Campos, Carlos; de Oliveira, Aldair José; Machado, Sérgio; Maranhao Neto, Geraldo AlbuquerqueTranscranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique increasingly explored for Parkinson's disease (PD). Although evidence is still inconsistent, there are preliminary findings suggesting its efficacy to improve motor function in individuals with PD, as the role of secondary motor areas remains unclear. The goal of this study was to investigate the effects of left dorsolateral prefrontal cortex (DLPFC) tDCS on balance and functional mobility of individuals with PD. Seventeen individuals with PD, on-medication, aged between 40 and 90 years were recruited to enroll in a double-blind, randomized, cross-over trial. Each participant completed two conditions at least 48h apart, namely anodal-tDCS and sham-tDCS (placebo). The a-tDCS condition targeted the left DLPC (F3) and was applied during 20min using a 2mA current intensity. In the sham-tDCS condition, electrode position remained the same but the stimulator was turned off after 30s. Functional mobility and balance were assessed using the Berg Balance Scale, Dynamic Gait Index and Timed Up and Go. There were significant differences between conditions on all outcome measures, as the a-tDCS condition was associated with better performance in comparison to the sham condition (p<0.05). Our findings suggest that a-tDCS on the left DLPFC improves balance and functional mobility in comparison to sham-tDCS. Compensatory mechanisms that support motor function in individuals with PD may have been enhanced by a-tDCS on the DLPFC, leading to improved functional mobility and balance. Future trials should explore left DLPFC stimulation with larger samples and compare t-DCS protocols targeting several brain regions.
- Chronic effects of aerobic exercise on panic disorder: a systematic review of randomized and non-randomized trialsPublication . Lattari, Eduardo; Paes, Flávia; Machado, Ana; Rocha, Nuno Barbosa Ferreira; Nardi, Antônio Egidio; Machado, SérgioIn general, most studies have supported an association between the acute effects of exercise and a reduced state anxiety, but failed to completely explain the relationship between the chronic effect of exercise and anxiety traits. The aim of this study was to systematically review the literature regarding the chronic effect of exercise on symptoms associated with panic disorder. The studies were retrieved from a MEDLINE/PubMed, ISI Web of Knowledge and SciELO. We adopted PICOS’s strategy recommended to determine the eligibility criteria. The survey was conducted using an advanced search in the ISI Web of Science and MEDLINE / PubMed with MeSH terms and Entry Terms for the keywords “Panic Disorder” basis and “Exercise”. Boolean operators “AND” and “OR” were used separately or in combination. Two independent researchers performed the selection of studies; in case of disagreement they sought a consensus on the selection. A total of 265 articles were identified: 199 articles from PubMed/Medline, 63 articles from ISI Web of Science and 3 articles by manual searches. Thus, 31 articles were analyzed by the eligibility criteria and the exclusion criteria, a total of five studies included in the systematic review. The regular practice of aerobic exercise seems to be an appropriate intervention to promote improvements in the severity of anxiety symptoms in PD patients.
- Effects of dual-task interventions on gait performance of patients with Parkinson’s Disease: A systematic reviewPublication . Santos, Luís A. A.; Campos, Carlos; Bento, Teresa; Lattari, Eduardo; Nardi, Antônio Egidio; Rocha, Nuno; Machado, SérgioParkinson’s disease is characterized by motor and non-motor symptoms that impair patients’ gait performance, especially while performing dual/concurrent tasks. These deficits impair patients’ daily function, because dual-tasking is a crucial ability in terms of everyday living. The aim of this study was to systematically review the effects of dual task interventions on gait performance of patients with Parkinson’s disease. Studies were retrieved from MEDLINE/PubMed, LILACS and SciELO. We used the PICOS strategy to determine eligibility criteria. The search strategy included an advanced search on the included databases, using the following search query: “Parkinson’s Disease” AND “Double Task” OR “Concurrent Tasks” OR “Gait” AND “Walk”. Study selection was carried out by two independent researchers and a third one was called when consensus was needed. A total of 188 articles were identified: 169 articles from Medline/PubMed, 10 articles in SciELO, 8 articles in LILACS and 1 item from manual searches. A total of 56 articles were analyzed regarding the eligibility and exclusion criteria based on full text. A final total of 7 studies were included in the systematic review. The different types of dual-task interventions reported (dance, sound stimuli, visual and somatosensory) were associated to improvements in several gait performance indicators of Parkinson’s disease patients, including gait speed, stride time and length, cadence and step length. External stimuli seem to play a critical role on specific training effects on dual-task gait performance.
- Effects on volume load and ratings of perceived exertion in individuals advanced weight-training after transcranial direct current stimulationPublication . Lattari, Eduardo; Filho, Blair José Rocha; Junior, Sidnei Jorge Fonseca; Murillo-Rodriguez, Eric; Rocha, Nuno; Machado, Sérgio; Neto, Geraldo Albuquerque MaranhãoLattari, E, Rosa Filho, BJ, Fonseca Junior, SJ, Murillo-Rodriguez, E, Rocha, N, Machado, S, and Maranhão Neto, GA. Effects on volume load and ratings of perceived exertion in individuals' advanced weight training after transcranial direct current stimulation. J Strength Cond Res 34(1): 89–96, 2020—The aim of this study was investigate the effects of transcranial direct current stimulation (tDCS) on volume load and ratings of perceived exertion. Fifteen young healthy individuals, aged between 20 and 30 years in advanced strength training were recruited. Test and retest of the 10 maximum repetitions (10RM) were performed to determine the reliability of load used. Subjects performed 3 experimental conditions in a randomized, double-blinded crossover design: anodic stimulation (a-tDCS), cathodic stimulation (c-tDCS), and sham (2 mA for 20 minutes targeting the dorsolateral prefrontal cortex left). Immediately after the experimental conditions, subjects completed 1 set of maximum repetitions with 10RM load (volume load) and answered to OMNI-RES (poststimulation) (level of significance p ≤ 0.05). The volume load showed main effect for condition (F(2, 28) = 164.801; p < 0.001). In poststimulation, a-tDCS was greater than c-tDCS (p ≤ 0.001) and sham (p ≤ 0.001). For ratings of perceived exertion (OMNI-RES), the results showed main effect for condition (F(2, 28) = 9.768; p ≤ 0.05). In poststimulation, c-tDCS was greater than a-tDCS (p ≤ 0.05) and sham (p ≤ 0.05). We conclude that the use of a-tDCS may promote increase in volume load for the LP45 exercise. Moreover, higher volume loads are necessary to maximize muscle strength and anabolism.
- Exercise induced neuroplasticity to enhance therapeutic outcomes of cognitive remediation in schizophrenia: Analyzing the role of brain-derived neurotrophic factorPublication . Campos, C.; Rocha, Nuno; Lattari, Eduardo; Nardi, António E.; Machado, SérgioCognitive impairment is a major manifestation of schizophrenia and a crucial treatment target as these deficits are closely related to patients' functional outcomes. Cognitive remediation is the gold-standard practice to address cognitive deficits in schizophrenia. There is clear evidence stating that cognitive remediation improves cognitive function and promotes structural neuroplastic changes in patients with schizophrenia, with brain-derived neurotrophic factor (BDNF) expression emerging as a potential biomarker for its efficacy. This is particularly important as there is clear evidence relating atypical BDNF expression to cognitive impairment in patients with schizophrenia. Despite the valuable role of cognitive remediation in the management of schizophrenia, there is still a need to develop methods that allow maximizing its efficacy.
- Exercise-induced neuroprotective effects on neurodegenerative diseases: the key role of trophic factorsPublication . Campos, Carlos; Rocha, Nuno; Lattari, Eduardo; Paes, Flávia; Nardi, António E.; Machado, SérgioAge-related neurodegenerative disorders, like Alzheimer’s or Parkinson’s disease, are becoming a major issue to public health care. Currently, there is no effective pharmacological treatment to address cognitive impairment in these patients. Here, we aim to explore the role of exercise-induced trophic factor enhancement in the prevention or delay of cognitive decline in patients with neurodegenerative diseases.
- From mind to body: is mental practice effective on strength gains? A meta-analysisPublication . Manochio, João Paulo; Lattari, Eduardo; Portugal, Eduardo Matta Mello; Monteiro-Junior, Renato Sobral; Paes, Flávia; Budde, Henning; Tarso Veras Farinatti, Paulo de; Arias-Carrión, Oscar; Wegner, Mirko; Carta, Mauro Giovanni; Mura, Gioia; Rocha, Nuno; Almada, Leonardo Ferreira; Nardi, Antonio Egidio; Yuan, Ti-Fei; Machado, SergioMental practice is an internal reproduction of a motor act (whose intention is to promote learning and improving motor skills). Some studies have shown that other cognitive strategies also increase the strength and muscular resistance in healthy people by the enhancement of the performance during dynamic tasks. Mental training sessions may be primordial to improving muscle strength in different subjects. The aim of this study was to systematically review and meta-analiyze studies that assessed whether mental practice is effective in improving muscular strength. We conducted an electronic-computed search in Pub-Med/Medline and ISI Web of Knowledge, Scielo and manual searchs, searching papers written in English between 1991 and 2014. There were 44 studies in Pub-Med/Medline, 631 in ISI Web of Knowledge, 11 in Scielo and 3 in manual searchs databases. After exclusion of studies for duplicate, unrelated to the topic by title and summary, different samples and methodologies, a meta-analysis of 4 studies was carried out to identify the dose-response relationship. We did not find evidence that mental practice is effective in increasing strength in healthy individuals. There is no evidence that mental practice alone can be effective to induce strength gains or to optimize the training effects.