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Percorrer por autor "Cunha, Joana"

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  • CGRP suppresses protective SiglecFhi Neutrophil development in Neonatal Group B Streptococcus Pneumonia
    Publication . Lorga, Inês; Teixeira, Ana Sofia; Carvalho, Bárbara; Soares, Joana; Ribeiro, Nuno; Cardoso, Marcos S.; Cunha, Joana; Santos, Joana; Silva, Regina A.; Vilanova, Manuel; Andrade, Elva Bonifácio; Bonifácio Andrade, Elva; Silva, Regina
    Neonatal pneumonia, a leading cause of morbidity and mortality, is frequently caused by Group B Streptococcus (GBS). The mechanisms underlying protective immunity to this pathogen in the neonatal lung remain incompletely understood. Using a clinically relevant neonatal mouse model of GBS pneumonia, we investigated the immune mechanisms influencing disease severity. We demonstrate that neutrophils are effectively recruited to the lungs of infected neonates, but their phenotype differs with disease severity. In pups with moderate disease, we observe significant infiltration of SiglecFhi neutrophils, a phenotype associated with enhanced phagocytic capacity and bacterial clearance. In contrast, pups with severe disease failed to develop SiglecFhi neutrophils, resulting in reduced bacterial clearance and worsened pathology. We further show that severity is associated with increased expression of calcitonin gene-related peptide (CGRP) in the lungs. CGRP suppressed neutrophil activation into the SiglecFhi phenotype, thereby limiting their antibacterial function. Our findings show that GBS exploits the neuroimmune axis to evade host immunity through CGRP-mediated suppression of neutrophil activation.
    2025-09-11Artigo de investigação Acesso aberto Ver mais
  • The effect of music on brain activity an emotional state
    Publication . Cunha, Joana; Gomes, Paulo Veloso; Marques, António; Pereira, Javier
    This study explores the potential of music as a therapy element in digital therapy programs to improve mental health and well-being. Music induces an emotional component in the individual that translates into changes in their brain activity, which can be monitored through electroencephalography. A scoping review was conducted to identify the most recent relevant publications related to the effect of music on brain activity and emotional state in digital therapy programs. From 585 identified publications, six relevant publications were selected that meet all the requirements defined in the study
    2021-10-11Documento de conferência Acesso aberto Ver mais