Browsing by Issue Date, starting with "2021-10-11"
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- Proteomic profiling of the B cell immune synapsePublication . Cunha, Diogo Francisco Martins; Pérez, Sara Hernández; Vieira, Mónica; Mattila, PietaThe imune system is responsible for eliminating threatening organisms and toxins, as well as for avoiding autoimmune responses that could be potentially harmful to the human tissues. Through special features of the imune cells, which can detect a massive variety of structures specific to pathogens, the imune system can mediate the adequate response to each specific situation. B cells are considered focal elements of the adaptative imune response since the recognition of pathogen’s antigens, and consequently activation and differentiation of B cells, results in the capture and elimination of the hazardous microbes and toxins. In order to successfully recognize potential threats, B cells are equipped with B cell receptors or BCRs. Antigen binding to the BCRs triggers na enormous number of downstream events in the cells, orchestrating numerous processes such as antigen internalization and actin reorganization. Despite the importance pf B cell responses for the imune system, many molecular players behind the regulation of the BCR signalling complexes and its interplay with other celular processes such as antigen internalization and cytoskeletal rearrangements are still unknown or poorly understood. Therefore, this work aims to set up and optimize a new pull-down method for the isolation of proteins recruited to the imune synapse site following BCR activation. Mass spectometry (MS) protein analysis will reveal potential candidates to regulate the immunological synapse formation and, ultimately the imune response.
- The effect of music on brain activity an emotional statePublication . Cunha, Joana; Gomes, Paulo Veloso; Marques, António; Pereira, JavierThis study explores the potential of music as a therapy element in digital therapy programs to improve mental health and well-being. Music induces an emotional component in the individual that translates into changes in their brain activity, which can be monitored through electroencephalography. A scoping review was conducted to identify the most recent relevant publications related to the effect of music on brain activity and emotional state in digital therapy programs. From 585 identified publications, six relevant publications were selected that meet all the requirements defined in the study
- A importância das agências de comunicação: estudo de casoPublication . Coimbra, Bruna Silveira; Gonçalves, Maria José AngélicoThe purpose of this study is to highlight the importance of communication agencies as an instrument capable of generating returns and supporting the growth of SMEs. Communication agencies have gained more and more space in the business world. This space was gradually conquered due to the evolution of ICTs that brought a multitude of benefits to the business world, from the optimization of processes, the increase in productivity, the improvement of internal communication and external communication, in relation to the latter, the ICT provided the possibility of offering a personalized service to its customers, in order to create a more personal and lasting relationship. Regardless of whether the company is a multinational or a small business, it is important that the company knows how to communicate with its audience, and it is in this context that communication agencies find their market segment. These agencies know the potential of digital and are specialized in developing digital communication for the growth and success of companies in order to ensure effective results of business communication in the digital sphere. The aim of this work is to identify the importance of communication agencies for the success of SMEs, as well as to show the services that are provided by them and how it is advantageous to hire their services by organizations. The methodology used to achieve the objective was, in addition to reviewing the literature in the area, a case study was carried out on a communication agency, DIGMA. The results of the study allowed us to conclude that DIGMA has successfully managed to create a broad portfolio of customers, essentially SMEs, having contributed to these small businesses migrating to the digital sphere, expanding their market share outside its borders, diversified, well, your audience.
- Fotografia e representação: a redistribuição dos lugares na fotografia participativaPublication . Campos, Isabel Maria Ferreira de Sousa Leal Costa; Baptista, Adriana; Leal, JoãoO presente Ensaio visa refletir sobre o imaginário usado para representar grupos vulneráveis e marginalizados da sociedade e considerar novas formas de abordagem. Adotam-se formas alternativas de autoria na produção de imagens, a partir de um projeto fotográfico participativo que remodela a posição autoral tradicional do fotógrafo por meio da colaboração da pessoa fotografada, desmontando a ideia do fotógrafo como observador especial e privilegiado. Numa estratégia pautada pela valorização da dimensão do encontro entre aquele que fotografa e aquele que é fotografado, questiona-se a definição convencional de autoria individual e as relações entre o fotógrafo e os seus sujeitos. Neste estudo, destacam-se as várias questões que gravitam em torno da representação fotográfica e ensaia-se a possibilidade subversiva de um desvio as convenções da fotografia documental através de um projeto prático de fotografia participativa/colaborativa. Partindo, no contexto da toxicodependência, da identidade do sujeito, constrói- se uma história visual, tomando como hipótese a redistribuição de lugares na fotografia. Será também a volta desta redistribuição que se deverá analisar até que ponto a fotografia documental pode beneficiar com a introdução de práticas colaborativas e participativas. Simultaneamente, avalia-se se estas práticas fotográficas podem oferecer uma compreensão mais matizada, complexa e diversificada nas representações fotográficas de grupos vulneráveis e minorias (e ponderamos uma redefinição do papel do fotógrafo no contexto da fotografia contemporânea). Os resultados demonstram que o ato fotográfico pode assumir uma inter-relação humana entre o registo e a sequência do acontecimento onde o fotógrafo faz algo para além de fotografar e onde o fotografado faz o acontecimento, mas também o seu registo, com um poder de decisão do que mostra.