Browsing by Author "Correia, Joana"
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- Bioactivity of ionic liquids based on valproate in the human osteoclastogenesisPublication . Correia, Joana; Ferraz, Ricardo; Costa-Rodrigues, João; Fernandes, Maria Helena; Branco, Luís C.; Noronha, João Paulo; Petrovski, eljko; Prudêncio, CristinaIonic Liquids (ILs) are salts (with at least one organic cation), that have a melting point lower than 100º C. The interest in these compounds has been increasing as well as the number of applications where they can be used. Their first applications were on batteries and in organic synthesis and soon they started to be applied on health sciences. With this work we intend to study the biological properties of ILs based on valproate, and evaluate their modulation potential on human osteoclastogenesis.
- Fattymess: fat diet-induced obesity in melanoma metastasisPublication . Correia, Joana; Costa, Raquel; Prudêncio, Cristina; Soares, Raquel; Coelho, PedroMelanoma is the most aggressive skin cancer characterized by a high metastatic potential and poor survival rate, leading to major morbidity/mortality. Overweight, obesity and diet composition have been identified as risk factors for many types of cancers. However, there are cancers where obesity is associated with favorable outcomes and this has been coined the “obesity paradox”. Preliminary data obtained by our research group disclosed paradoxical findings unveiling that obesity act as a two-edged sword in melanoma: potentiating primary tumor growth, and vascularity/angiogenesis, but at the same time decrease metastatic potential, thus preventing secondary tumor growth. In this exploratory research project, we propose to further explore and deepen the impact that fat-rich diets and obesity partake in melanoma etiology