Browsing by Author "Calhau, C."
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- Noncompliance to iodine supplementation recommendation is a risk factor for iodine insufficiency in Portuguese pregnant women: results from the IoMum cohortPublication . Matta Coelho, C.; Guimarães, J.; Bracchi, I.; Xavier Moreira, N.; Pinheiro, C.; Ferreira, P.; Pestana, D.; Barreiros Mota, I.; Cortez, A.; Prucha, C.; Martins, C.; Pinto, E.; Almeida, A.; Delerue-Matos, Cristina; Dias, C. C.; Moreira-Rosário, A.; Ribeiro de Azevedo, L. F.; Fernandes, Virgínia; Ramalho, C.; Calhau, C.; Brantsæter, A.-L.; Costa Leite, J.; Keating, E.Purpose After a recommendation for iodine supplementation in pregnancy has been issued in 2013 in Portugal, there were no studies covering iodine status in pregnancy in the country. The aim of this study was to assess iodine status in pregnant women in Porto region and its association with iodine supplementation. Methods A cross-sectional study was conducted at Centro Hospitalar Universitário São João, Porto, from April 2018 to April 2019. Pregnant women attending the 1st trimester ultrasound scan were invited to participate. Exclusion criteria were levothyroxine use, gestational age < 10 and ≥ 14 weeks, non-evolutive pregnancy at recruitment and non-signing of informed consent. Urinary iodine concentration (UIC) was measured in random spot urine by inductively coupled plasma-mass spectrometry. Results Median UIC was 104 μg/L (IQR 62–189) in the overall population (n = 481) of which 19% had UIC < 50 µg/L. Forty three percent (n = 206) were not taking an iodine-containing supplement (ICS) and median UIC values were 146 µg/L (IQR 81–260) and 74 µg/L (IQR 42–113) in ICS users and non-users, respectively (p < 0.001). Not using an ICS was an independent risk factor for iodine insufficiency [adjusted OR (95% CI) = 6.00 (2.74, 13.16); p < 0.001]. Iodised salt use was associated with increased median iodine-to-creatinine ratio (p < 0.014). Conclusions A low compliance to iodine supplementation recommendation in pregnancy accounted for a mild-to-moderately iodine deficiency. Our results evidence the need to support iodine supplementation among pregnant women in countries with low household coverage of iodised salt.
- Noncompliance to iodine supplementation recommendation is a risk factor for iodine insufficiency in portuguese pregnant women: results from the IoMum cohortPublication . Matta Coelho, C.; Guimarães, J.; Bracchi, I.; Xavier Moreira, N.; Pinheiro, C.; Ferreira, P.; Pestana, D.; Barreiros Mota, I.; Cortez, A.; Prucha, C.; Martins, C.; Pinto, E.; Almeida, A.; Delerue‑Matos, C.; C. Dias, C.; Moreira‑Rosário, A.; F. Ribeiro de Azevedo, L.; Cruz Fernandes, V.; Ramalho, C.; Calhau, C.; ‑L. Brantsæter, A.; Costa Leite, J.; Keating, E.After a recommendation for iodine supplementation in pregnancy has been issued in 2013 in Portugal, there were no studies covering iodine status in pregnancy in the country. The aim of this study was to assess iodine status in pregnant women in Porto region and its association with iodine supplementation. A cross-sectional study was conducted at Centro Hospitalar Universitário São João, Porto, from April 2018 to April 2019. Pregnant women attending the 1st trimester ultrasound scan were invited to participate. Exclusion criteria were levothyroxine use, gestational age<10 and≥14 weeks, non-evolutive pregnancy at recruitment and non-signing of informed consent. Urinary iodine concentration (UIC) was measured in random spot urine by inductively coupled plasma-mass spectrometry. Median UIC was 104 μg/L (IQR 62–189) in the overall population (n=481) of which 19% had UIC<50 µg/L. Forty three percent (n=206) were not taking an iodine-containing supplement (ICS) and median UIC values were 146 µg/L (IQR 81–260) and 74 µg/L (IQR 42–113) in ICS users and non-users, respectively (p<0.001). Not using an ICS was an independent risk factor for iodine insufciency [adjusted OR (95% CI)=6.00 (2.74, 13.16); p<0.001]. Iodised salt use was associated with increased median iodine-to-creatinine ratio (p<0.014). A low compliance to iodine supplementation recommendation in pregnancy accounted for a mild-to-moderately iodine defciency. Our results evidence the need to support iodine supplementation among pregnant women in countries with low household coverage of iodised salt.
- The Fatty Acid Profile in Patients with Newly Diagnosed Diabetes: Why It Could Be UnsuspectedPublication . Castro-Correia, C.; Sousa, S.; Norberto, S.; Matos, C.; Domingues, Valentina; Fontoura, M.; Calhau, C.Several studies have shown a link between proinflammatory activity and the presence or deficit of some fatty acids. Inflammation is associated with several diseases including diabetes. Objective. To characterize and compare the fatty acids profiles in children with inaugural type 1 diabetes, diabetic children (at least 1 year after diagnosis), and healthy children. Design. Plasma fatty acids profiles in children with inaugural diabetes, children with noninaugural diabetes, and controls, all of whom were prepubescent with a BMI < 85th percentile, were evaluated. Results. Omega-3 fatty acid levels were higher in recently diagnosed subjects with diabetes than in controls. The ratio of omega-6/omega-3 fatty acids was higher in the control population. Omega-6 fatty acid levels were higher in the nonrecent diabetic subjects than in the children with recently diagnosed diabetes, and the levels were higher in the nonrecent diabetes group compared to the control group. Conclusion. Our findings showed higher levels of alpha-linolenic acid, EPA, and DHA, as well as mono- and polyunsaturated fatty acids, in diabetic children. These findings reinforce the importance of precocious nutritional attention and intervention in the treatment of diabetic children.