Browsing by Author "Artner, Christoph"
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- 45Ti - Titanium: from cyclotron production to potential applications evaluationPublication . Costa, Pedro; Metello, Luís F.; Cunha, Lídia; Lass, Piotr; Currie, Geoff; Johnson, Richard R.; Gelbart, W.; Obermair, J.; Artner, Christoph; Alves, Francisco; Naia, M. DuarteIntroduction: Thousands of radioisotopes are known and virtually all may be artificially produced, however clinical applications of PET imaging are mainly based on 18F, 11C, 13N and 68Ga. This trend could change in the near future, since several groups worldwide are busy developing very promising new entities aiming to contribute for spreading the use and efficacy of clinical diagnostic using Nuclear Medicine imaging techniques. Our group is developing 45Ti-Titanium, assuming it as a potential candidate, since presenting interesting properties: physical half-life of 3.09h, together with relevant chemical properties, that enable radiolabelling with bifunctional chelates, ligands or could even be useful for studies concerning the distribution of new titanium-based chemotherapy drugs or titanium oxide nanoparticles. Considering that data characterizing excitation functions is necessary for radionuclide optimal production, this work aims to disseminate results regarding the determination of excitation function of 45Sc(p,n)45Ti reaction, studied as a potential route to produce 45Ti in low energy cyclotrons.
- Cyclotron produced 45Ti-Titanium: why & how… so WHY NOT?Publication . Costa, Pedro; Metello, Luís F.; Cunha, Lídia; Johnson, Richard R.; Mattei, Lidia; Gelbart, W.; Obermair, J.; Dietl, B.; Nauschnig, R.; Artner, Christoph; Lass, Piotr; Currie, Geoff; Carmo, Sérgio; Alves, Francisco; Naia, M. DuarteThere are many different radioisotopes well known and characterized for medical use, with almost all of them able to be artificially produced. Nevertheless, routine clinical applications of PET imaging are still based on 18F, in excess of 97% of the cases, with 11C, 13N and 68Ga sharing the few remaining situations. This trend could change in the – hopingly near – future, since several groups worldwide are busy developing very promising new processes using less conventional radionuclides, aiming to contribute for spreading the use and efficacy of clinical diagnostic using Nuclear Medicine imaging techniques, evolving more and more in the direction of personalized medicine, an worldwide growing societal request. Our group is busy studying 45Ti, interested by its many interesting properties and assuming it as a high-potential candidate: in fact 45Ti presents a physical half-life of 3.09h (50% higher than 18F) together with relevant chemical properties, that enable radiolabelling with bifunctional chelates, ligands or even to radiolabel titanium (di)oxide nanoparticles. Considering that data characterizing excitation functions are mandatory for radionuclide optimal production, the present work refers to our results regarding the 45Sc(p,n)45Ti nuclear reaction, being studied as a potential route to efficiently produce 45Ti in low energy cyclotrons.
- Experimental results on excitation functions for 45Ti direct production on low energy - medical - cyclotronsPublication . Costa, Pedro; Metello, Luís F.; Cunha, Lídia; Johnson, Richard R.; Gelbart, W.; Obermair, J.; Artner, Christoph; Carmo, Sérgio; Alves, Francisco; Naia, M. Duarte
- Should new Nuclear Reactors be considered as an option to solve Technetium shortage problem?Publication . Metello, Luís F.; Cunha, Lídia; Costa, Pedro; Vieira, Domingos; Alves, Francisco; Botelho, Maria Filomena; Gelbart, W.; Artner, Christoph; Nader, Michael; Schibli, Roger; Jensen, MikaelWorldwide, more than 80% of Nuclear Medicine procedures use a radiotracer produced through a 99Mo/99mTc generator - 99mTc – Technetium 99metastable. Most of the radiochemistry and equipments is optimized for this radioisotope characteristics already for more than 35 years, making it very difficult to replace. Worldwide production of 99Mo is based essentially with only five Nuclear Reactors that are becoming obsolete and fragile with aging, shutting down more and more frequently as they approach the end of their shelf-life. Seeking for solutions, some Governments – and the EU – plan to build new dedicated Nuclear Reactor(s). Our work defends another option.
- Using Monte Carlo to approach 45Ti direct production on low energy - medical - cyclotronsPublication . Costa, Pedro; Cunha, Lídia; Johnson, Richard R.; Gelbart, W.; Artner, Christoph; Alves, Francisco; Naia, M. Duarte; Metello, Luís F.