ESS - APCT - Anatomia Patológica, Citológica e Tanatológica
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Browsing ESS - APCT - Anatomia Patológica, Citológica e Tanatológica by Author "Abreu, Catarina M."
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- Phenotypic analysis of urothelial exfoliated cells in bladder cancer via microfluidic immunoassays: Sialyl-Tn as a novel biomarker in liquid biopsiesPublication . Carvalho, Sandra; Abreu, Catarina M.; Ferreira, Dylan; Lima, Luís; Santos, Lúcio L.; Ribeiro, Ricardo; Grenha, Vânia; Martínez-Fernández, Mónica; Duenas, Marta; Suárez-Cabrera, Cristian; Paramio, Jesus M.; Diéguez, Lorena; Freitas, Paulo P.; Oliveira, Marta I.Bladder cancer is the most common malignancy of the urinary tract, having one of the highest recurrence rates and progression from non-muscle to muscle invasive bladder cancer that commonly leads to metastasis. Cystoscopy and urine cytology are the standard procedures for its detection but have limited clinical sensitivity and specificity. Herein, a microfluidic device, the UriChip, was developed for the enrichment of urothelial exfoliated cells from fresh and frozen urine, based on deformability and size, and the cancer-associated glycan Sialyl-Tn explored as a putative bladder cancer urinary biomarker.