ESEIG - UTC Engenharia Biomédica
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Percorrer ESEIG - UTC Engenharia Biomédica por autor "Fernandes, Ruben"
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- Dermic diffusion and stratum corneum: a state of the art review of mathematical modelsPublication . Couto, Ana; Fernandes, Ruben; Cordeiro, M. Natália D. S.; Reis, Sara S.; Ribeiro, Rogério T.; Pessoa, Ana S. MouraTransdermal biotechnologies are an ever increasing field of interest, due to the medical and pharmaceutical applications that they underlie. There are several mathematical models at use that permit a more inclusive vision of pure experimental data and even allow practical extrapolation for new dermal diffusion methodologies. However, they grasp a complex variety of theories and assumptions that allocate their use for specific situations. Models based on Fick's First Law found better use in contexts where scaled particle theory Models would be extensive in time-span but the reciprocal is also true, as context of transdermal diffusion of particular active compounds changes. This article reviews extensively the various theoretical methodologies for studying dermic diffusion in the rate limiting dermic barrier, the stratum corneum, and systematizes its characteristics, their proper context of application, advantages and limitations, as well as future perspectives.
- Quinoxaline, its derivatives and applications: a state of the art reviewPublication . Pereira, Joana A.; Pessoa, Ana S. Moura; Cordeiro, M. Natália D. S.; Fernandes, Ruben; Prudencio, Cristina; Noronha, Joao Paulo; Vieira, MónicaQuinoxaline derivatives are an important class of heterocycle compounds, where N replaces some carbon atoms in the ring of naphthalene. Its molecular formula is C8H6N2, formed by the fusion of two aromatic rings, benzene and pyrazine. It is rare in natural state, but their synthesis is easy to perform. In this review the State of the Art will be presented, which includes a summary of the progress made over the past years in the knowledge of the structure and mechanism of the quinoxaline and quinoxaline derivatives, associated medical and biomedical value as well as industrial value. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.