Dermic diffusion and stratum corneum: a state of the art review of mathematical models

Couto, Ana; Fernandes, Ruben; Cordeiro, M. Natália D. S.; Reis, Sara S.; Ribeiro, Rogério T.; Pessoa, Ana S. Moura

http://hdl.handle.net/10400.22/3481

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Authors

Couto, Ana

Fernandes, Ruben

Cordeiro, M. Natália D. S.

Reis, Sara S.

Ribeiro, Rogério T.

Pessoa, Ana S. Moura

Abstract(s)

Transdermal biotechnologies are an ever increasing ﬁeld of interest, due to the medical and pharmaceutical applications that they underlie. There are several mathematical models at use that permit a more inclusive vision of pure experimental data and even allow practical extrapolation for new dermal diffusion methodologies. However, they grasp a complex variety of theories and assumptions that allocate their use for speciﬁc situations. Models based on Fick's First Law found better use in contexts where scaled particle theory Models would be extensive in time-span but the reciprocal is also true, as context of transdermal diffusion of particular active compounds changes. This article reviews extensively the various theoretical methodologies for studying dermic diffusion in the rate limiting dermic barrier, the stratum corneum, and systematizes its characteristics, their proper context of application, advantages and limitations, as well as future perspectives.

Keywords

Transdermal diffusion Mathematical diffusion models Fick's Law Sensors Hybrid approach

URI

http://hdl.handle.net/10400.22/3481

Citation

Couto, A., Fernandes, R., Cordeiro, M. N. S., Reis, S. S., Ribeiro, R. T., & Pessoa, A. M. (2014). Dermic diffusion and stratum corneum: A state of the art review of mathematical models. Journal of Controlled Release, 177, 74–83. doi:10.1016/j.jconrel.2013.12.005