A carregar...
Publicação
Dermic diffusion and stratum corneum: a state of the art review of mathematical models
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 1.09 MB | Adobe PDF |
Orientador(es)
Resumo(s)
Transdermal biotechnologies are an ever increasing field of interest, due to the medical and pharmaceutical
applications that they underlie. There are several mathematical models at use that permit a more inclusive vision
of pure experimental data and even allow practical extrapolation for new dermal diffusion methodologies.
However, they grasp a complex variety of theories and assumptions that allocate their use for specific situations.
Models based on Fick's First Law found better use in contexts where scaled particle theory Models would be
extensive in time-span but the reciprocal is also true, as context of transdermal diffusion of particular active
compounds changes. This article reviews extensively the various theoretical methodologies for studying dermic
diffusion in the rate limiting dermic barrier, the stratum corneum, and systematizes its characteristics, their
proper context of application, advantages and limitations, as well as future perspectives.
Descrição
Palavras-chave
Transdermal diffusion Mathematical diffusion models Fick's Law Sensors Hybrid approach
Contexto Educativo
Citação
Couto, A., Fernandes, R., Cordeiro, M. N. S., Reis, S. S., Ribeiro, R. T., & Pessoa, A. M. (2014). Dermic diffusion and stratum corneum: A state of the art review of mathematical models. Journal of Controlled Release, 177, 74–83. doi:10.1016/j.jconrel.2013.12.005
Editora
Elsevier