ESS - DM - Bioestatística e Bioinformática Aplicadas à Saúde
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Percorrer ESS - DM - Bioestatística e Bioinformática Aplicadas à Saúde por orientador "Alves, Sandra Maria"
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- Applied cancer epidemiology: Survival analysis and occupational risk assessmentPublication . Coutinho, Carolina Silva; Bento, Maria José; Alves, Sandra MariaCancer epidemiology is dedicated to investigating the factors that influence the occurrence, progression, and outcomes of oncological diseases. This report presents two projects developed during an internship at the Epidemiology Service of IPO-Porto, with the aim of contributing to the advancement of knowledge in this field. The first project focused on the development of a computational tool, implemented in R, designed to automate the generation of regional (Northern Region) and national cancer survival reports. These reports are based on user-provided databases and include estimates of observed survival, net survival, age-standardized net survival, and log-rank tests for comparing net survival by sex, age group, and region. The goal was to facilitate the systematic production and dissemination of this information, promoting its regular use. The second project consisted of a study on occupational cancer in Portugal. In the absence of individual-level occupational exposure data, a population-based approach was adopted to provide preliminary insights into the association between occupation and cancer risk across Portuguese municipalities. As a result, the first national cancer survival report in Portugal was produced, and essential insights into occupational cancer risk were generated through an innovative approach adapted to the limitations of the available data.
- Understanding the clinical research lifecycle: An internship experience with application to a rare disease studyPublication . Machado, Raquel Oliveira; Santos, Janete; Alves, Sandra MariaClinical research is critical in advancing medical knowledge and improving patient care. This reports refers to the activities carried out during the internship at the Clinical Research Support Unit of the Faculty of Medicine of the University of Porto. The internship involved several stages of clinical study management: study registration, collection and organization of clinical data, and creation of case report forms. The F-CHECK study, a multicentre observational study, whose objective was to evaluate the prevalence and clinical characteristics of Fabry diseaase (FD) in the Portuguese population with idiopathic cardiomyopathies, was one of the main projects where activities were carried out. Fourteen patients (3,4%) with FD were reported from 409 participants. Non-parametric statistical tests were used with na α=0.05, along with Effect size measures. FD patients showed significant differences compared to non-FD, mainly in the hypertrophic group: prolonaged QRS (Ƿ=0.029), right bundle branch block (Ƿ˂0.001), fascicular block (Ƿ=0.033), and inferolateral fibrosis (Ƿ˂0.001). These results highlight the importance of systematic screening for FD among Portuguese patients with idiophatic cardiomyopathies, extending beyond the classic hypertrophic presentations. The internship conributed to the consolidation of competencies in clinical research and data analyis, strengthening preparation for future academic and professionals challenges.