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Cinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugs

2020Journal article Open access
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dc.contributor.authorSilva, Ana Teresa
dc.contributor.authorBento, Clara M.
dc.contributor.authorPena, Ana C.
dc.contributor.authorFigueiredo, Luísa M.
dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorAguiar, Luísa
dc.contributor.authorSilva, Tânia
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorGomes, Maria Salomé
dc.contributor.authorTeixeira, Cátia
dc.contributor.authorGomes, Paula
dc.date.accessioned2021-11-05T15:38:13Z
dc.date.available2021-11-05T15:38:13Z
dc.date.issued2020
dc.description.abstractCinnamic acids are compounds of natural origin that can be found in many different parts of a wide panoply of plants, where they play the most diverse biological roles, often in a conjugated form. For a long time, this has been driving Medicinal Chemists towards the investigation of the therapeutic potential of natural, semi-synthetic, or fully synthetic cinnamic acid conjugates. These efforts have been steadily disclosing promising drug leads, but a wide chemical space remains that deserves to be further explored. Amongst different reported approaches, the combination or conjugation of cinnamic acids with known drugs has been addressed in an attempt to produce either synergistic or multi-target action. In this connection, the present review will focus on efforts of the past decade regarding conjugation with cinnamic acids as a tool for the rescuing or the repurposing of classical antimalarial drugs, and also on future perspectives in this particular field of research. pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, A. T., Bento, C. M., Pena, A. C., Figueiredo, L. M., Prudêncio, C., Aguiar, L., Silva, T., Ferraz, R., Gomes, M. S., Teixeira, C., & Gomes, P. (2020). Cinnamic Acid Conjugates in the Rescuing and Repurposing of Classical Antimalarial Drugs. Molecules, 25(1), 66. https://www.mdpi.com/1420-3049/25/1/66pt_PT
dc.identifier.doi10.3390/molecules25010066pt_PT
dc.identifier.eissn1420-3049
dc.identifier.urihttp://hdl.handle.net/10400.22/18820
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1420-3049/25/1/66pt_PT
dc.subjectAmidept_PT
dc.subjectAminoquinolinept_PT
dc.subjectAntimalarialpt_PT
dc.subjectAntioxidantpt_PT
dc.subjectAntiparasiticpt_PT
dc.subjectAntiproliferativept_PT
dc.subjectArtemisininpt_PT
dc.subjectChloroquinept_PT
dc.subjectCinnamicpt_PT
dc.subjectIonic liquidpt_PT
dc.subjectPrimaquinept_PT
dc.subjectRescuingpt_PT
dc.subjectRepurposingpt_PT
dc.titleCinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage15pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume25pt_PT
person.familyNamePrudêncio
person.familyNameFerraz
person.givenNameCristina
person.givenNameRicardo
person.identifier1200571
person.identifier.ciencia-idC81E-F4EE-FADE
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.orcid0000-0002-9920-936X
person.identifier.orcid0000-0002-1761-117X
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id6508057930
person.identifier.scopus-author-id24464208500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication881a8ad5-ab13-4e49-89f4-08ca61cc81e3
relation.isAuthorOfPublicationa5a8faa7-12a5-4b1c-bced-44c895677397
relation.isAuthorOfPublication.latestForDiscovery881a8ad5-ab13-4e49-89f4-08ca61cc81e3

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