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Molecularly imprinted sensor for voltammetric detection of norfloxacin

2015-11Journal article Restricted access
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dc.contributor.authorSilva, Hélder da
dc.contributor.authorPacheco, João
dc.contributor.authorSilva, Joana
dc.contributor.authorViswanathan, Subramanian
dc.contributor.authorDelerue-Matos, Cristina
dc.date.accessioned2015-12-23T12:29:36Z
dc.date.available2015-12-23T12:29:36Z
dc.date.issued2015-11
dc.description.abstractIn this work, a norfloxacin selective modified glassy carbon electrode (GCE) based on a molecularly imprinted polymer (MIP) as electrochemical sensor was developed. A suspension of multi-walled carbon nanotubes (MWCNTs) was deposited on the electrode surface. Subsequently, a molecularly imprinted film was prepared by electropolymerization, via cyclic voltammetry of pyrrole (PPy) in the presence of norfloxacin (NFX) as the template molecule. A control electrode (NIP) was also prepared. Scanning electron microscopy (SEM) and cyclic voltammetry in a ferrocyanide solution were performed for morphological and electrochemical characterisation, respectively. Several experimental parameters were studied and optimised. For quantification purposes the MIP/MWCNT/GCE was immersed in NFX solutions for 10 min, and the detection was performed in voltammetric cell by square wave voltammetry. The proposed sensor presented a linear behaviour, between peak current intensity and logarithmic concentration of NFX between 1 × 10−7 and 8 × 10−6 M. The obtained results presented good precision, with a repeatability of 4.3% and reproducibility of 9% and the detection limit was 4.6 × 10−8 M (S/N = 3). The developed sensor displayed good selectivity and operational lifetime, is simple to fabricate and easy to operate and was successfully applied to the analysis of NFX in urine samples.pt_PT
dc.identifier.doi10.1016/j.snb.2015.04.125pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/7240
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.relation.ispartofseriesSensors and Actuators B: Chemical;Vol. 219
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0925400515006097pt_PT
dc.subjectNorfloxacinpt_PT
dc.subjectElectrochemical sensorpt_PT
dc.subjectMolecularly imprinted polymerpt_PT
dc.subjectMulti-walled carbon nanotubespt_PT
dc.titleMolecularly imprinted sensor for voltammetric detection of norfloxacinpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage307pt_PT
oaire.citation.startPage301pt_PT
oaire.citation.titleSensors and Actuators B: Chemicalpt_PT
oaire.citation.volume219pt_PT
person.familyNameDelerue-Matos
person.givenNameCristina
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.orcid0000-0002-3924-776X
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id6603741848
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication09f6a7bd-2f15-42b0-adc5-04bd22210519
relation.isAuthorOfPublication.latestForDiscovery09f6a7bd-2f15-42b0-adc5-04bd22210519

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