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Retinal capillary nonperfusion in preclinical diabetic retinopathy

2023-10-11Journal article Open access
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dc.contributor.authorSantos, Torcato
dc.contributor.authorSantos, Ana Rita
dc.contributor.authorAlmeida, Ana Catarina
dc.contributor.authorRocha, Ana Cláudia
dc.contributor.authorReste-Ferreira, Débora
dc.contributor.authorMarques, Inês Pereira
dc.contributor.authorMartinho, António Cunha-Vaz
dc.contributor.authorMendes, Luís
dc.contributor.authorFoote, Katharina
dc.contributor.authorCunha-Vaz, José
dc.date.accessioned2024-07-08T08:31:21Z
dc.date.available2024-07-08T08:31:21Z
dc.date.issued2023-10-11
dc.description.abstractThe aim of the study was to identify retinal microvascular changes using optical coherence tomography angiography (OCTA) in type 2 diabetes (T2D) patients with preclinical retinopathy identified by ultra-widefield fundus photography (UWF-FP). This is a cross-sectional observational study. All patients underwent UWF-FP 200° examinations with OPTOS California (Optos, Dunfermline, UK) and Cirrus AngioPlex® spectral-domain (SD)-OCTA 3 × 3 mm acquisitions (ZEISS, Dublin, CA, USA). The absence of visible lesions was identified using UWF-FP. One hundred and ninety three eyes of individuals with T2D with no visible lesions in the fundus and identified in a screening setting were included in the study. Skeletonized vessel density (SVD), perfusion density (PD), and areas of capillary nonperfusion (CNP) values on SD-OCTA were significantly decreased when compared with healthy population (p < 0.001). SVD and CNP values of the superficial capillary plexus (SCP) were more frequently decreased (35% and 45%, respectively) than SVD values of the deep capillary plexus (DCP) (9% and 15%, respectively), demonstrating that diabetic microvascular changes occur earlier in the SCP than in the DCP. The ischemic phenotype, identified by a definite decrease in SVD or CNP in the SCP may, therefore, be identified in the preclinical stage of diabetic retinal disease. Retinal capillary nonperfusion detected by OCTA metrics of SVD and CNP can be identified in the central retina in eyes with T2D before development of visible lesions in the retina. Our findings confirm the relevance of OCTA to identify macular microvascular changes in the initial stages of diabetic retinopathy, allowing the identification of its ischemic phenotype very early in the disease process.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantos, T., Santos, A. R., Almeida, A. C., Rocha, A. C., Reste-Ferreira, D., Marques, I. P., Cunha-Vaz Martinho, A., Mendes, L., Foote, K., & Cunha-Vaz, J. (2023). Retinal capillary nonperfusion in preclinical diabetic retinopathy. Ophthalmic Research, 66(1), 1327–1334. https://doi.org/10.1159/000534553pt_PT
dc.identifier.doi10.1159/000534553pt_PT
dc.identifier.eissn1423-0259
dc.identifier.issn0030-3747
dc.identifier.urihttp://hdl.handle.net/10400.22/25737
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherKargerpt_PT
dc.relationThis work was supported by AIBILI and the Fundo de Inovação, Tecnologia e Economia Circular (FITEC)—Programa Interface (FITEC/CIT/2018/2).pt_PT
dc.relation.publisherversionhttps://karger.com/ore/article/66/1/1327/865056/Retinal-Capillary-Nonperfusion-in-Preclinicalpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectDiabetic retinopathypt_PT
dc.subjectPreclinical diabetic retinopathypt_PT
dc.subjectOptical coherence tomography angiographypt_PT
dc.subjectRetina nonperfusionpt_PT
dc.subjectUltra-widefield imagingpt_PT
dc.titleRetinal capillary nonperfusion in preclinical diabetic retinopathypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1334pt_PT
oaire.citation.startPage1327pt_PT
oaire.citation.titleOphthalmic Researchpt_PT
oaire.citation.volume66 (1)pt_PT
person.familyNameSantos
person.givenNameAna Rita
person.identifier.ciencia-id0911-4138-0C3A
person.identifier.orcid0000-0003-0139-0285
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd71931b8-d869-4334-993c-ba14ad713f01
relation.isAuthorOfPublication.latestForDiscoveryd71931b8-d869-4334-993c-ba14ad713f01

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