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Emergence of drug-resistance in HIV dynamics under distinct HAARTregimes

2016Journal article Restricted access
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dc.contributor.authorPinto, Carla M.A.
dc.contributor.authorCarvalho, Ana R.M.
dc.date.accessioned2017-01-09T11:15:56Z
dc.date.embargo2117
dc.date.issued2016
dc.description.abstractIn this paper we propose a model for the dynamics of HIV epidemics under distinct HAART regimes, and study the emergence of drug-resistance. The model predicts HIV dynamics of untreated HIV patients for all stages of the infection. We compute the local and the global stability of the disease-free equilibrium of the model. We simulate the model for two distinct HIV patients, the rapid progressors and the long-term non-progressors. We study the effects of equal RTI and PI efficacies, as well as distinct drug efficacies, namely RTI-based and PI-based therapeutics. Treatment is initiated when the CD4+ T cells count is less than 350 cells mm−3. The PI-based drugs seem to produce better outcomes, with respect to disease progression, than RTI-based regimes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.cnsns.2015.06.019pt_PT
dc.identifier.issn1007-5704
dc.identifier.urihttp://hdl.handle.net/10400.22/9148
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.ispartofseriesCommunications in Nonlinear Science and Numerical Simulation;Vol. 30, Issues 1–3,
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1007570415002208pt_PT
dc.subjectHAART regimespt_PT
dc.subjectDrug-resistancept_PT
dc.subjectRapid progressorspt_PT
dc.subjectLong-term-non-progressorspt_PT
dc.titleEmergence of drug-resistance in HIV dynamics under distinct HAARTregimespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage226pt_PT
oaire.citation.issue1-3pt_PT
oaire.citation.startPage207pt_PT
oaire.citation.titleCommunications in Nonlinear Science and Numerical Simulationpt_PT
oaire.citation.volume30pt_PT
person.familyNamePinto
person.givenNameCarla
person.identifier.orcid0000-0002-0729-1133
person.identifier.ridJ-5221-2013
person.identifier.scopus-author-id14326048800
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationedfd0bf4-9f73-47ee-817a-860e3d088994
relation.isAuthorOfPublication.latestForDiscoveryedfd0bf4-9f73-47ee-817a-860e3d088994

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