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POPs’ effect on cardiometabolic and inflammatory profile in a sample of women with obesity and hypertension

2018-11Journal article Open access
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dc.contributor.authorFerro, Ana
dc.contributor.authorTeixeira, Diana
dc.contributor.authorPestana, Diogo
dc.contributor.authorMonteiro, Rosário
dc.contributor.authorSantos, Cristina C.
dc.contributor.authorDomingues, Valentina F.
dc.contributor.authorPolónia, Jorge
dc.contributor.authorCalhau, Conceição
dc.date.accessioned2020-07-10T12:29:03Z
dc.date.available2020-07-10T12:29:03Z
dc.date.issued2018-11
dc.description.abstractPersistent organic pollutants (POPs) are man-made compounds with metabolic disruption impact. We investigated the effect of POP exposure in the cardiometabolic and inflammatory profile in a population of women with obesity and hypertension. In 43 premenopausal women (22 treated vs. 21 nontreated) undergoing bariatric surgery, blood and adipose tissue samples (visceral (vAT) and abdominal subcutaneous (scAT)) were collected. Median concentrations of ∑HCH and ∑POPs in vAT were significantly higher in treated women. VAT ∑HCH and scAT ∑HCH and ∑POPs concentrations were positively correlated with systolic blood pressure in the non-treated group. Our findings suggest that exposure to POPs and its accumulation in vAT and circulating in plasma may be associated to a higher cardiovascular risk in women with obesity and hypertension, with or without antihypertensive treatment.pt_PT
dc.description.sponsorshipThis work was supported by FCT (Fundo Social Europeu, Programa Operacional Potencial Humano da EU (POPH); PEst-OE/SAU/UI0038/2011; SFRH/BD/46640/2008, SFRH/BD/64691/2009), and Projetos de Investigação na Pré-graduação 2011, Universidade do Porto.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1080/19338244.2018.1535480pt_PT
dc.identifier.issn2154-4700
dc.identifier.urihttp://hdl.handle.net/10400.22/16087
dc.language.isoengpt_PT
dc.publisherTaylor & Francispt_PT
dc.relationEFFECTS OF PERSISTANT ORGANIC POLLUTANTS POPS ON ADIPOCYTE BIOLOGY: PUTATIVE INVOLVEMENT IN THE METABOLIC SYNDROME
dc.relation.publisherversionhttps://www.tandfonline.com/doi/full/10.1080/19338244.2018.1535480pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCardiometabolic riskpt_PT
dc.subjectHypertensionpt_PT
dc.subjectInflammationpt_PT
dc.subjectObesitypt_PT
dc.subjectPersistent organic pollutantspt_PT
dc.titlePOPs’ effect on cardiometabolic and inflammatory profile in a sample of women with obesity and hypertensionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEFFECTS OF PERSISTANT ORGANIC POLLUTANTS POPS ON ADIPOCYTE BIOLOGY: PUTATIVE INVOLVEMENT IN THE METABOLIC SYNDROME
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F46640%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F64691%2F2009/PT
oaire.citation.endPage321pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage310pt_PT
oaire.citation.titleArchives of Environmental & Occupational Healthpt_PT
oaire.citation.volume74pt_PT
oaire.fundingStreamSFRH
person.familyNameDomingues
person.givenNameValentina Maria Fernandes
person.identifier.ciencia-id4E16-791D-6664
person.identifier.orcid0000-0003-3472-849X
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscoverybe653ab6-34ec-4329-972a-eee990a7ec66
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