Publication
Biological and Medicinal Properties of Natural Chromones and Chromanones
| datacite.subject.fos | Engenharia e Tecnologia | |
| datacite.subject.sdg | 09:Indústria, Inovação e Infraestruturas | |
| dc.contributor.author | Gaspar, Alexandra | |
| dc.contributor.author | Garrido, E. Manuela P. J. | |
| dc.contributor.author | Borges, Fernanda | |
| dc.contributor.author | Garrido, Jorge M. P. J. | |
| dc.date.accessioned | 2025-02-07T16:46:47Z | |
| dc.date.available | 2025-02-07T16:46:47Z | |
| dc.date.issued | 2024 | |
| dc.description.abstract | Emerging threats to human health require a concerted effort to search for new treatment therapies. One of the biggest challenges is finding medicines with few or no side effects. Natural products have historically contributed to major advances in the field of pharmacotherapy, as they offer special characteristics compared to conventional synthetic molecules. Interest in natural products is being revitalized, in a continuous search for lead structures that can be used as models for the development of new medicines by the pharmaceutical industry. Chromone and chromanones are recognized as privileged structures and useful templates for the design of diversified therapeutic molecules with potential pharmacological interest. Chromones and chromanones are widely distributed in plants and fungi, and significant biological activities, namely antioxidant, anti-inflammatory, antimicrobial, antiviral, etc., have been reported for these compounds, suggesting their potential as lead drug candidates. This review aims to update the literature published over the last 6 years (2018–2023) regarding the natural occurrence and biological activity of chromones and chromanones, highlighting the recent findings and the perspectives that they hold for future research and applications namely in health, cosmetic, and food industries. | eng |
| dc.description.sponsorship | This work was funded by FEDER funds through the Operational Programme Competitiveness Factors-COMPETE and national funds by FCT–Foundation for Science and Technology under research grants (DOI:10.54499/UIDB/00081/2020, LA/P/0056/2020 (IMS), EXPL/MED-QUI/1156/2021). A.G. gratefully acknowledges for the financial support through contract DL 57/2016/CP1454/CT0008 (DOI: 10.54499/DL57/2016/CP1454/CT0008). | |
| dc.identifier.citation | ACS Omega 2024, 9, 20, 21706–21726 | |
| dc.identifier.doi | 10.1021/acsomega.4c00771 | |
| dc.identifier.issn | 2470-1343 | |
| dc.identifier.uri | http://hdl.handle.net/10400.22/29435 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | ACS Publications | |
| dc.relation | Chemistry Research Unit of University of Porto | |
| dc.relation.hasversion | https://pubs.acs.org/doi/10.1021/acsomega.4c00771?ref=pdf | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | Antibacterial Activity | |
| dc.subject | Bioactivity | |
| dc.subject | Fungi | |
| dc.subject | Inhibition | |
| dc.subject | Pharmaceuticals | |
| dc.title | Biological and Medicinal Properties of Natural Chromones and Chromanones | eng |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Chemistry Research Unit of University of Porto | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00081%2F2020/PT | |
| oaire.citation.endPage | 21726 | |
| oaire.citation.issue | 20 | |
| oaire.citation.startPage | 21706 | |
| oaire.citation.title | ACS Omega | |
| oaire.citation.volume | 9 | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| relation.isProjectOfPublication | 2a43ea7f-a750-492c-bafc-d818da22f041 | |
| relation.isProjectOfPublication.latestForDiscovery | 2a43ea7f-a750-492c-bafc-d818da22f041 |