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Abstract(s)
This work reports a novel way of producing an inexpensive substrate support to assemble a sensing
film, designed for the electrical transduction of an intended biomolecule. The support uses cellulose
paper as substrate, made hydrophobic with solid wax and covered by a home-made conductive ink
having graphite as core material. The hydrophobicity of the paper was confirmed by contact angle
measurements and the conductive ink composition was optimized with regard to its adhesion,
conductivity, and thermal stability. This support was further modified targeting its application in
quantitative analysis. Carnitine (CRT) was selected as target compound, a cancer biomarker. The
recognition material consisted of an antibody-like receptor film for CRT, tailored on the support
and prepared by electrically-sustained polymerization of 3,4-ethylenedioxythiophene (EDOT) or
dodecylbenzenesulfonic acid (DBS). Fourier transform infrared spectroscopy (FTIR) and Raman
spectroscopy analysis confirmed the presence of the polymeric film on the support, and the
performance of the devices was extensively evaluated with regard to linear response ranges, selectivity,
applicability, and reusability. Overall, the paper-based sensors offer simplicity of fabrication, low cost
and excellent reusability features. The design could also be extended to other applications in electricalbased
approaches to be used in point-of-care (POC).
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Publisher
Nature Publishing Group