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Xanthohumol-supplemented beer modulates angiogenesis and inflammation in a skin wound healing model. Involvement of local adipocytes

2012Journal article Open access
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dc.contributor.authorNegrão, Rita
dc.contributor.authorCosta, Raquel
dc.contributor.authorDuarte, Delfim
dc.contributor.authorGomes, Tiago Taveira
dc.contributor.authorCoelho, Pedro
dc.contributor.authorGuimarães, João T.
dc.contributor.authorGuardão, Luísa
dc.contributor.authorAzevedo, Isabel
dc.contributor.authorSoares, Raquel
dc.date.accessioned2019-07-01T13:52:04Z
dc.date.available2019-07-01T13:52:04Z
dc.date.issued2012
dc.description.abstractAngiogenesis and inflammation are two intermingled processes that play a role in wound healing. Nevertheless, whenever exacerbated, these processes result in nonhealing wounds. Xanthohumol (XN), a beer-derived polyphenol, inhibits these processes in many physiopathological situations. This study aimed at examining whether XN ingestion affects wound healing. Wistar rats drinking water, 5% ethanol, stout beer (SB) or stout beer supplemented with 10 mg/L XN (Suppl SB) for 4 weeks, were subjected to a 1.5 cm full skin-thickness longitudinal incision, and further maintained under the same beverage conditions for another week. No differences in beverage consumption or body weight were found throughout the study but food intake decreased in every group relative to controls. Consumption of Suppl SB resulted in decreased serum VEGF levels (18.42%), N-acetylglucosaminidase activity (27.77%), IL1β concentration (9.07%), and NO released (77.06%), accompanied by a reduced redox state as observed by increased GSH/GSSG ratio (to 198.80%). Also, the number of blood vessels within the wound granulation tissue seems to reduce in animals drinking Suppl SB (23.08%). Interestingly, SB and primarily Suppl SB showed a tendency to increase adipocyte number (to 194.26% and 156.68%, respectively) and reduce adipocyte size (4.60% and 24.64%, respectively) within the granuloma. Liver function and metabolism did not change among the animal groups as analyzed by plasma biochemical parameters, indicating no beverage toxicity. This study shows that XN intake in its natural beer context reduced inflammation, oxidative stress, and angiogenesis, ameliorating the wound healing process, suggesting that this polyphenol may exert beneficial effect as a nutritional supplement.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNegrão, R., Costa, R., Duarte, D., Gomes, T. T., Coelho, P., Guimarães, J. T., Guardão, L., Azevedo, I., & Soares, R. (2012). Xanthohumol-supplemented beer modulates angiogenesis and inflammation in a skin wound healing model. Involvement of local adipocytes. Journal of Cellular Biochemistry, 113(1), 100–109. https://doi.org/10.1002/jcb.23332
dc.identifier.doi10.1002/jcb.23332pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/14187
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationSFRM/BD/41888/2007pt_PT
dc.relationAngioPaX - ELUCIDATING THE ANGIO/VASCULOGENIC PARADOX IN DIABETES
dc.relationStrategic Project - UI 38 - 2011-2012
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.23332pt_PT
dc.subjectAcetylglucosaminidasept_PT
dc.subjectAdipocytespt_PT
dc.subjectAnimalspt_PT
dc.subjectDietary Supplementspt_PT
dc.subjectFlavonoidspt_PT
dc.subjectGlutathionept_PT
dc.subjectGranulomapt_PT
dc.subjectInflammationpt_PT
dc.subjectInterleukin-1betapt_PT
dc.subjectNeovascularization, Physiologicpt_PT
dc.subjectNitric Oxidept_PT
dc.subjectOxidation-Reductionpt_PT
dc.subjectOxidative Stresspt_PT
dc.subjectPropiophenonespt_PT
dc.subjectRatspt_PT
dc.subjectRats, Wistarpt_PT
dc.subjectSkinpt_PT
dc.subjectVascular Endothelial Growth Factor Apt_PT
dc.subjectWound Healingpt_PT
dc.subjectBeerpt_PT
dc.titleXanthohumol-supplemented beer modulates angiogenesis and inflammation in a skin wound healing model. Involvement of local adipocytespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAngioPaX - ELUCIDATING THE ANGIO/VASCULOGENIC PARADOX IN DIABETES
oaire.awardTitleStrategic Project - UI 38 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-OSM%2F102083%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FSAU%2FUI0038%2F2011/PT
oaire.citation.endPage109pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage100pt_PT
oaire.citation.titleJournal of Cellular Biochemistrypt_PT
oaire.citation.volume113pt_PT
oaire.fundingStream5876-PPCDTI
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCoelho
person.givenNamePedro
person.identifier.ciencia-idBE18-3DB2-8D79
person.identifier.orcid0000-0002-2343-1108
person.identifier.ridAAZ-9239-2020
person.identifier.scopus-author-id57214054449
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationeb030614-4140-437b-8ac3-f59c52566ecf
relation.isAuthorOfPublication.latestForDiscoveryeb030614-4140-437b-8ac3-f59c52566ecf
relation.isProjectOfPublicationac856e83-d532-48b1-a08f-59b4b63d9bf3
relation.isProjectOfPublication489ef5d0-6d8c-4b4a-abfb-971d63808907
relation.isProjectOfPublication.latestForDiscoveryac856e83-d532-48b1-a08f-59b4b63d9bf3

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