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A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid

2019Journal article Open access
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dc.contributor.authorTeixeira, Sónia
dc.contributor.authorSantos, Miguel M.
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorFernandes, Maria H.
dc.contributor.authorCosta-Rodrigues, Joao
dc.contributor.authorBranco, Luís C.
dc.date.accessioned2019-11-19T17:29:30Z
dc.date.available2020-10-01T00:30:23Z
dc.date.issued2019
dc.description.abstractNovel ionic liquids and organic salts based on mono- or dianionic zoledronate and protonated superbases, choline and n-alkylmethylimidazolium cations, were prepared and characterized by spectroscopic and thermal analyses. Most of the prepared salts display amorphous structures and very high solubility in water and saline solutions, especially the dianionic salts. Among the zoledronate-based ionic compounds, those containing choline [Ch] and methoxyethylmethylimidazolium [C3 OMIM] cations appear to have significant cytotoxicity against human osteosarcoma cells (MG63) and low toxicity toward healthy skin fibroblast cells. Because osteosarcoma is a bone pathology characterized by an increase in bone turnover rate, the results presented herein may be a promising starting point for the development of new ionic pharmaceutical drugs against osteosarcoma.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTeixeira, S., Santos, M. M., Ferraz, R., Prudêncio, C., Fernandes, M. H., Costa-Rodrigues, J., & Branco, L. C. (2019). A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid. ChemMedChem, 14(20), 1767–1770. https://doi.org/10.1002/cmdc.201900397
dc.identifier.doi10.1002/cmdc.201900397
dc.identifier.urihttp://hdl.handle.net/10400.22/14844
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationPEst-C/LA0006/ 2013pt_PT
dc.relationPOCI-01- 0145-FEDER-007265pt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201900397pt_PT
dc.titleA Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acidpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQUI-QOR%2F32406%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCTM%2F103664%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F50006%2F2013/PT
oaire.citation.endPage1770pt_PT
oaire.citation.issue20pt_PT
oaire.citation.startPage1767pt_PT
oaire.citation.titleChemMedChempt_PT
oaire.citation.volume14pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
person.familyNameFerraz
person.familyNamePrudêncio
person.familyNameCosta-Rodrigues
person.givenNameRicardo
person.givenNameCristina
person.givenNameJoao
person.identifier1200571
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.ciencia-idC81E-F4EE-FADE
person.identifier.ciencia-id7412-B006-2120
person.identifier.orcid0000-0002-1761-117X
person.identifier.orcid0000-0002-9920-936X
person.identifier.orcid0000-0003-1375-8067
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id24464208500
person.identifier.scopus-author-id6508057930
person.identifier.scopus-author-id8558383400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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