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Development of a SPE–UHPLC–MS/MS methodology for thedetermination of non-steroidal anti-inflammatory and analgesicpharmaceuticals in seawaterPaula

2015-03Journal article Open access
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dc.contributor.authorPaíga, Paula
dc.contributor.authorLolić, Aleksandar
dc.contributor.authorHellebuyck, Floris
dc.contributor.authorSantos, Lúcia H.M.L.M.
dc.contributor.authorCorreia, Manuela
dc.contributor.authorDelerue-Matos, Cristina
dc.date.accessioned2015-12-23T15:49:29Z
dc.date.available2015-12-23T15:49:29Z
dc.date.issued2015-03
dc.description.abstractAn analytical methodology for the simultaneous determination of seven pharmaceuticals and two metabolites belonging to the non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics therapeutic groups was developed based on off-line solid-phase extraction and ultra-high performance liquid chromatography coupled to tandem mass spectrometry (SPE–UHPLC–MS/MS). Extraction conditions were optimized taking into account parameters like sorbent material, sample volume and sample pH. Method detection limits (MDLs) ranging from 0.02 to 8.18 ng/L were obtained. This methodology was successfully applied to the determination of the selected pharmaceuticals in seawater samples of Atlantic Ocean in the Northern Portuguese coast. All the pharmaceuticals have been detected in the seawater samples, with pharmaceuticals like ibuprofen, acetaminophen, ketoprofen and the metabolite hydroxyibuprofen being the most frequently detected at concentrations that can reach some hundreds of ng/L.pt_PT
dc.identifier.doi10.1016/j.jpba.2014.06.017pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/7249
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.relation.ispartofseriesJournal of Pharmaceutical and Biomedical Analysis;Vol. 106
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0731708514003057pt_PT
dc.subjectNon-steroidal anti-inflammatory drugspt_PT
dc.subjectAnalgesicspt_PT
dc.subjectUHPLC–MS/MSSPEpt_PT
dc.subjectSeawaterpt_PT
dc.titleDevelopment of a SPE–UHPLC–MS/MS methodology for thedetermination of non-steroidal anti-inflammatory and analgesicpharmaceuticals in seawaterPaulapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage70pt_PT
oaire.citation.startPage61pt_PT
oaire.citation.titleJournal of Pharmaceutical and Biomedical Analysispt_PT
oaire.citation.volume106pt_PT
person.familyNamePaíga
person.familyNameDelerue-Matos
person.givenNamePaula
person.givenNameCristina
person.identifier1668889
person.identifier.ciencia-id331A-5D6A-D3C8
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.orcid0000-0002-9593-1355
person.identifier.orcid0000-0002-3924-776X
person.identifier.ridQ-4930-2018
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id6506638953
person.identifier.scopus-author-id6603741848
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4a0677dc-0b54-4831-aa9a-4a73f0df911d
relation.isAuthorOfPublication09f6a7bd-2f15-42b0-adc5-04bd22210519
relation.isAuthorOfPublication.latestForDiscovery09f6a7bd-2f15-42b0-adc5-04bd22210519

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