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Biological potential, gastrointestinal digestion, absorption, and bioavailability of algae-derived compounds with neuroprotective activity: a comprehensive review

2022-05-28Journal article Open access
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dc.contributor.authorMartins, Bruna
dc.contributor.authorVieira, Mónica
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorGrosso, Clara
dc.contributor.authorSoares, Cristina
dc.date.accessioned2022-11-23T16:54:02Z
dc.date.available2022-11-23T16:54:02Z
dc.date.issued2022-05-28
dc.description.abstractCurrently, there is no known cure for neurodegenerative disease. However, the available therapies aim to manage some of the symptoms of the disease. Human neurodegenerative diseases are a heterogeneous group of illnesses characterized by progressive loss of neuronal cells and nervous system dysfunction related to several mechanisms such as protein aggregation, neuroinflammation, oxidative stress, and neurotransmission dysfunction. Neuroprotective compounds are essential in the prevention and management of neurodegenerative diseases. This review will focus on the neurodegeneration mechanisms and the compounds (proteins, polyunsaturated fatty acids (PUFAs), polysaccharides, carotenoids, phycobiliproteins, phenolic compounds, among others) present in seaweeds that have shown in vivo and in vitro neuroprotective activity. Additionally, it will cover the recent findings on the neuroprotective effects of bioactive compounds from macroalgae, with a focus on their biological potential and possible mechanism of action, including microbiota modulation. Furthermore, gastrointestinal digestion, absorption, and bioavailability will be discussed. Moreover, the clinical trials using seaweed-based drugs or extracts to treat neurodegenerative disorders will be presented, showing the real potential and limitations that a specific metabolite or extract may have as a new therapeutic agent considering the recent approval of a seaweed-based drug to treat Alzheimer’s disease.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMartins, B.; Vieira, M.; Delerue-Matos, C.; Grosso, C.; Soares, C. Biological Potential, Gastrointestinal Digestion, Absorption, and Bioavailability of Algae-Derived Compounds with Neuroprotective Activity: A Comprehensive Review. Mar. Drugs 2022, 20, 362. https://doi.org/10.3390/md20060362pt_PT
dc.identifier.doi10.3390/md20060362pt_PT
dc.identifier.eissn1660-3397
dc.identifier.urihttp://hdl.handle.net/10400.22/21050
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1660-3397/20/6/362pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAlzheimer’s diseasept_PT
dc.subjectHuntington’s diseasept_PT
dc.subjectNeuroprotectionpt_PT
dc.subjectParkinson’s diseasept_PT
dc.subjectSeaweedspt_PT
dc.titleBiological potential, gastrointestinal digestion, absorption, and bioavailability of algae-derived compounds with neuroprotective activity: a comprehensive reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage55pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleMarine Drugspt_PT
oaire.citation.volume20pt_PT
person.familyNameVieira
person.givenNameMónica
person.identifier.orcid0000-0002-9614-9031
person.identifier.ridD-8977-2016
person.identifier.scopus-author-id24464652500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication55587c4b-3df0-4ff1-bade-587420940ecd
relation.isAuthorOfPublication.latestForDiscovery55587c4b-3df0-4ff1-bade-587420940ecd

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