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Seasonal influenza vaccine effectiveness in persons aged 15–64 years: a systematic review and meta-analysis

2023-08-04Journal article Open access
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dc.contributor.authorMartins, João Paulo
dc.contributor.authorSantos, Marlene
dc.contributor.authorMartins, André
dc.contributor.authorFelgueiras, Miguel
dc.contributor.authorSantos, Rui
dc.date.accessioned2023-09-18T15:51:42Z
dc.date.available2023-09-18T15:51:42Z
dc.date.issued2023-08-04
dc.description.abstractInfluenza is a respiratory disease caused by the influenza virus, which is highly transmissible in humans. This paper presents a systematic review and meta-analysis of randomized controlled trials (RCTs) and test-negative designs (TNDs) to assess the vaccine effectiveness (VE) of seasonal influenza vaccines (SIVs) in humans aged 15 to 64 years. An electronic search to identify all relevant studies was performed. The outcome measure of interest was VE on laboratory-confirmed influenza (any strain). Quality assessment was performed using the Cochrane risk-of-bias tool for RCTs and the ROBINS-I tool for TNDs. The search identified a total of 2993 records, but only 123 studies from 73 papers were included in the meta-analysis. Of these studies, 9 were RCTs and 116 were TNDs. The pooled VE was 48% (95% CI: 42–54) for RCTs, 55.4% (95% CI: 43.2–64.9) when there was a match between the vaccine and most prevalent circulating strains and 39.3% (95% CI: 23.5–51.9) otherwise. The TNDs’ adjusted VE was equal to 39.9% (95% CI: 31–48), 45.1 (95% CI: 38.7–50.8) when there was a match and 35.1 (95% CI: 29.0–40.7) otherwise. The match between strains included in the vaccine and strains in circulation is the most important factor in the VE. It increases by more than 25% when there is a match with the most prevalent circulating strains. The laboratorial method for confirmation of influenza is a possible source of bias when estimating VE.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMartins, J. P., Santos, M., Martins, A., Felgueiras, M., & Santos, R. (2023). Seasonal Influenza Vaccine Effectiveness in Persons Aged 15–64 Years: A Systematic Review and Meta-Analysis. 11 (8), 1–21. https://doi.org/10.3390/vaccines11081322pt_PT
dc.identifier.doi10.3390/vaccines11081322pt_PT
dc.identifier.eissn2076-393X
dc.identifier.urihttp://hdl.handle.net/10400.22/23553
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2076-393X/11/8/1322pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectInfluenzapt_PT
dc.subjectTest-negative designpt_PT
dc.subjectClinical trialspt_PT
dc.subjectEfficacypt_PT
dc.subjectEffectivenesspt_PT
dc.subjectStrainspt_PT
dc.titleSeasonal influenza vaccine effectiveness in persons aged 15–64 years: a systematic review and meta-analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage21pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleVaccinespt_PT
oaire.citation.volume11(8)pt_PT
person.familyNameOliveira Martins
person.familyNameSantos
person.givenNameJoão Paulo
person.givenNameMarlene
person.identifier955929
person.identifier1508370
person.identifier.ciencia-id6913-C065-48FF
person.identifier.ciencia-id8311-B967-31C4
person.identifier.orcid0000-0002-0474-1397
person.identifier.orcid0000-0001-5020-5942
person.identifier.scopus-author-id55838096100
person.identifier.scopus-author-id57110502000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication9d1f7388-bb3e-4f1d-bf41-08a589b1d6a8
relation.isAuthorOfPublication8ce9ee39-a4c6-46ae-99e2-49397b550f1b
relation.isAuthorOfPublication.latestForDiscovery9d1f7388-bb3e-4f1d-bf41-08a589b1d6a8

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