A carregar...
Publicação
Voltammetric quantification of fluoxetine: application to quality control and quality assurance processes
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 353.47 KB | Adobe PDF |
Orientador(es)
Resumo(s)
The oxidative behaviour of fluoxetine was studied at a glassy carbon electrode in various buffer systems and at different pH
using cyclic, differential pulse and square wave voltammetry. A new square wave voltammetric method suitable for the quality
control of fluoxetine in commercial formulations has been developed using a borate pH 9 buffer solution as supporting electrolyte.
Under optimized conditions, a linear response was obtained in the range 10 to 16 μM with a detection limit of 1.0 μM. Validation
parameters such as sensitivity, precision and accuracy were evaluated. The proposed method was successfully applied to the
determination of fluoxetine in pharmaceutical formulations. The results were statistically compared with those obtained by the
reference high-performance liquid chromatographic method. No significant differences were found between the methods.
Descrição
Palavras-chave
Fluoxetine Square wave voltammetry Oxidation Quality control Pharmaceutics
Contexto Educativo
Citação
10.38212/2224-6614.2477