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Potential therapeutic effects of physical exercise for bipolar disorder

2015Journal article Open access
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dc.contributor.authorSá Filho, Alberto Souza de
dc.contributor.authorSouza Moura, Antonio Marcos de
dc.contributor.authorLamego, Murilo Khede
dc.contributor.authorRocha, Nuno
dc.contributor.authorPaes, Flavia
dc.contributor.authorOliveira, Ana Cristina
dc.contributor.authorLattari, Eduardo
dc.contributor.authorRimes, Ridson
dc.contributor.authorManochio, Joao
dc.contributor.authorBudde, Henning
dc.contributor.authorWegner, Mirko
dc.contributor.authorMura, Gioia
dc.contributor.authorArias-Carrión, Oscar
dc.contributor.authorCheniaux, Elie
dc.contributor.authorYuan, Ti-Fei
dc.contributor.authorNardi, Antonio Egidio
dc.contributor.authorMachado, Sergio
dc.date.accessioned2016-01-08T13:00:17Z
dc.date.available2016-11-01T01:30:09Z
dc.date.issued2015
dc.description.abstractCognitive deficits are observed in a variety of domains in patients with bipolar disorder (BD). These deficits are attributed to neurobiological, functional and structural brain factors, particularly in prefrontal cortex. Furthermore, cortical alterations in each phase (mania/hypomania, euthymia and depression) are also present. A growing basis of evidence supports aerobic exercise as an alternative treatment method for BD symptoms. Its benefits for physical health in healthy subjects and some psychiatric disorders are fairly established; however evidence directly addressed to BD is scant. Lack of methodological consistency, mainly related to exercise, makes it difficult accuracy and extrapolation of the results. Nevertheless, mechanisms related to BD physiopathology, such as hormonal and neurotransmitters alterations and mainly related to brain-derived neurotrophic factors (BDNF) can be explored. BDNF, specially, have a large influence on brain ability and its gene expression is highly responsive to aerobic exercise. Moreover, aerobic exercise trough BDNF may induce chronic stress suppression, commonly observed in patients with BD, and reduce deleterious effects caused by allostatic loads. Therefore, it is prudent to propose that aerobic exercise plays an important role in BD physiopathological mechanisms and it is a new way for the treatment for this and others psychiatric disorders.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/7346
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBentham Science Publisherspt_PT
dc.relation.publisherversionhttp://www.ingentaconnect.com/content/ben/cnsnddt/2015/00000014/00000010/art00003pt_PT
dc.subjectneuroplasticitypt_PT
dc.subjectmaniapt_PT
dc.subjectexercisept_PT
dc.subjectdepressionpt_PT
dc.subjectbrain-derived neurotrophic factorpt_PT
dc.subjectBipolar disorderpt_PT
dc.titlePotential therapeutic effects of physical exercise for bipolar disorderpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1259pt_PT
oaire.citation.startPage1255pt_PT
oaire.citation.titleCNS and Neurological Disorders - Drug Targetspt_PT
oaire.citation.volume14pt_PT
person.familyNameRocha
person.givenNameNuno
person.identifier192266
person.identifier.ciencia-idAE16-A494-5F8B
person.identifier.orcid0000-0002-3139-2786
person.identifier.ridM-9821-2013
person.identifier.scopus-author-id32867975300
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication9e940914-601a-4978-8d5b-74e5ade7ada7
relation.isAuthorOfPublication.latestForDiscovery9e940914-601a-4978-8d5b-74e5ade7ada7

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