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Firefighters exposure to fire emissions: Impact on levels of biomarkers of exposure to polycyclic aromatic hydrocarbons and genotoxic/oxidative-effects

2020Journal article Restricted access
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dc.contributor.authorOliveira, Marta
dc.contributor.authorCosta, Solange
dc.contributor.authorVaz, Josiana
dc.contributor.authorFernandes, Adília
dc.contributor.authorSlezakova, Klara
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorCarmo Pereira, Maria
dc.contributor.authorMorais, Simone
dc.date.accessioned2023-11-09T11:05:39Z
dc.date.embargo2035
dc.date.issued2020
dc.description.abstractFirefighters represent one of the riskiest occupations, yet due to the logistic reasons, the respective exposure assessment is one of the most challenging. Thus, this work assessed the impact of firefighting activities on levels of urinary monohydroxyl-polycyclic aromatic hydrocarbons (OHPAHs; 1-hydroxynaphthalene, 1-hydroxyacenaphthene, 2-hydroxyfluorene, 1-hydroxyphenanthrene, 1-hydroxypyrene, 3-hydroxybenzo(a)pyrene) and genotoxic/oxidative-effect biomarkers (basal DNA and oxidative DNA damage) of firefighters from eight firehouses. Cardiac frequency, blood pressure and arterial oxygen saturation were also monitored. OHPAHs were determined by liquid-chromatography with fluorescence detection, while genotoxic/oxidative-effect biomarkers were assessed by the comet assay. Concentrations of total OHPAHs were up to 340% higher (p ≤ 0.05) in (non-smoking and smoking) exposed workers than in control subjects (non-smoking and non-exposed to combat activities); the highest increments were observed for 1-hydroxynaphthalene and 1-hydroxyacenaphthene (82–88% of ∑OHPAHs), and for 2-hydroxyfluorene (5–15%). Levels of biomarker for oxidative stress were increased in non-smoking exposed workers than in control group (316%; p ≤ 0.001); inconclusive results were found for DNA damage. Positive correlations were found between the cardiac frequency, ∑OHPAHs and the oxidative DNA damage of non-smoking (non-exposed and exposed) firefighters. Evidences were raised regarding the simultaneous use of these biomarkers for the surveillance of firefighters’ health and to better estimate the potential short-term health risks.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.jhazmat.2019.121179pt_PT
dc.identifier.issn0304-3894
dc.identifier.urihttp://hdl.handle.net/10400.22/23873
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationPCIF/SSO/ 0017/2018pt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationSFRH/BPD/100948/201pt_PT
dc.relationIndoor and Outdoor Exposure to Ultrafine Particles: the Implications for Public Health
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S0304389419311331pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectDNA damagept_PT
dc.subjectFirefightingpt_PT
dc.subjectHuman biomonitoringpt_PT
dc.subjectTobacco smokingpt_PT
dc.subjectUrinary monohydroxyl metabolitespt_PT
dc.titleFirefighters exposure to fire emissions: Impact on levels of biomarkers of exposure to polycyclic aromatic hydrocarbons and genotoxic/oxidative-effectspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleIndoor and Outdoor Exposure to Ultrafine Particles: the Implications for Public Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F50006%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBPD%2F105100%2F2014/PT
oaire.citation.startPage121179pt_PT
oaire.citation.titleJournal of Hazardous Materialspt_PT
oaire.citation.volume383pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamOE
person.familyNameMarques de Oliveira
person.familyNameSlezakova
person.familyNameDelerue-Matos
person.familyNameMorais
person.givenNameMarta Madalena
person.givenNameKlara
person.givenNameCristina
person.givenNameSimone
person.identifierE-1761-2011
person.identifier1921769
person.identifier1598822
person.identifier.ciencia-id0A1C-A89D-641A
person.identifier.ciencia-idD419-0115-8329
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.ciencia-idB111-BBFB-F200
person.identifier.orcid0000-0003-4150-0151
person.identifier.orcid0000-0001-5265-4186
person.identifier.orcid0000-0002-3924-776X
person.identifier.orcid0000-0001-6433-5801
person.identifier.ridK-8178-2013
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id57202841330
person.identifier.scopus-author-id16403150200
person.identifier.scopus-author-id6603741848
person.identifier.scopus-author-id7007053747
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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